High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer.
High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer.
复制标题
高水平的血管内皮生长因子及其受体（VEGFR-1，VEGFR-2，Neuropilin-1）与乳腺癌预后较差有关。
DOI：
10.1016/j.humpath.2008.06.004
复制
发表时间：
2008-12
期刊：
影响因子：
3.3
通讯作者：
Chung, Gina G.
中科院分区：
文献类型：
--
作者：
Ghosh, Sriparna;Sullivan, Catherine A. W.;Zerkowski, Maciej P.;Molinaro, Annette M.;Rimm, David L.;Camp, Robert L.;Chung, Gina G.
血管内皮生长因子已被证明在乳腺癌中上调。VEGFR-1和VEGFR-2是其作用的主要介导物。它可能与VEGFR-1和VEGFR-2一起，作为血管内皮生长因子的共同受体。虽然血管内皮生长因子对血管内皮细胞有重要作用，但血管内皮生长因子受体可能也存在于肿瘤细胞上。我们使用AQUA在一个大型乳腺癌组织微阵列上分析了肿瘤特异性表达的血管内皮生长因子、血管内皮生长因子受体-1、血管内皮生长因子受体-2和神经粘连蛋白-1。从642例原发性乳腺癌组织中构建了两重冗余阵列。然后用Aqua进行自动图像分析以确定定量表达分数。对来自冗余阵列的分数进行归一化和平均化。Kaplan-Meier生存分析显示，高水平的血管内皮生长因子、血管内皮生长因子受体-1、血管内皮生长因子受体-2和神经粘连蛋白-1均与生存率显著相关(Miller Siegmeund校正P值分别为0.0020、0.0160和0.0320)。此外，血管内皮生长因子和神经粘连蛋白-1与独立于其他标准预后因素的存活率显著相关。血管内皮生长因子及其受体VEGFR-1和VEGFR-2及神经粘连蛋白-1在乳腺癌组织中均有不同程度的表达，对预后有一定意义。有必要进一步研究这一发现的功能意义，以及这些生物标记物在其他肿瘤微环境特异室(如血管)中的预后价值。
Vascular endothelial growth factor has been shown to be upregulated in breast cancers. VEGFR-1 and VEGFR-2 are the principal mediators of its effects. Together with VEGFR-1 and VEGFR-2, neuropilin-1 may act as a co-receptor for VEGF. Although VEGF exerts important effects on endothelial cells, VEGFRs are likely present on tumor cells as well. We used AQUA to analyze tumor-specific expression of VEGF, VEGFR-1, VEGFR-2, and neuropilin-1 on a large cohort breast cancer tissue microarray. Two-fold redundant arrays were constructed from 642 cases of primary breast adenocarcinomas. Automated image analysis with AQUA was then performed to determine a quantitative expression score. Scores from redundant arrays were normalized and averaged. Kaplan-Meier survival analysis showed that high levels of VEGF, VEGFR-1, VEGFR-2, and neuropilin-1 were all significantly associated with survival (Miller Siegmeund corrected P value 0.0020, 0.0160, and 0.0320 respectively). In addition, VEGF and neuropilin-1 retained a significant association with survival independent of other standard prognostic factors. VEGF, VEGFR-1 and 2, and neuropilin-1 are expressed to varying degrees in primary breast cancers and have prognostic significance. Further study of the functional significance of this finding is warranted as well as the prognostic value of these biomarkers in other tumor microenvironment-specific compartments (e.g. vessels).
登录
查看更多内容
影响因子：
4
作者：
Bernatchez, PN;Rollin, S;Sirois, MG
通讯作者：
Sirois, MG
影响因子：
45.3
作者：
Eppenberger, U;Kueng, W;Eppenberger-Castori, S
通讯作者：
Eppenberger-Castori, S
影响因子：
6.2
作者：
Chung, GG;Yoon, HH;Burtness, BA
通讯作者：
Burtness, BA
影响因子：
0.7
作者：
Zhukova, LG;Zhukov, NV;Lichinitser, MR
通讯作者：
Lichinitser, MR
影响因子：
3.8
作者：
Rydén, L;Linderholm, B;Landberg, G
通讯作者：
Landberg, G