Lipidomic analysis reveals prostanoid profiles in human term pregnant myometrium
Lipidomic analysis reveals prostanoid profiles in human term pregnant myometrium
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DOI：
10.1016/j.plefa.2009.11.002
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发表时间：
2010-01-01
影响因子：
3
通讯作者：
Nicolaou, A.
中科院分区：
文献类型：
--
作者：
Durn, J. H.;Marshall, K. M.;Nicolaou, A.
前列腺素调节人类妊娠子宫肌层的活性，并且可以通过前列腺素受体的表征和前列腺素的组织浓度来了解其功能作用。我们应用脂质组学方法来阐明人类非临产和临产子宫肌层中前列腺素的概况。我们总共鉴定了十九种前列腺素，包括前列环素、血栓素、前列腺素和二氢前列腺素。前列环素是非临产和临产子宫肌层中主要的前列腺素类药物，PGD(2) 和 PGF(2α) 是第二丰富的。尽管临产组织中前列腺素总量有所增加，但 PGE(2) 和 13,14-二氢-15-酮-PGE(2) 是唯一在临产早期和晚期显着增加的前列腺素类药物（p
Prostanoids modulate the activity of human pregnant myometrium and their functional role can be appreciated through characterisation of prostanoid receptors and tissue concentration of prostanoids. We have applied a lipidomic approach to elucidate the profile of prostanoids in human non-labouring and labouring myometrium. We have identified a total of nineteen prostanoids including prostacyclin, thromboxanes, prostaglandins and dihydro-prostaglandins. Prostacyclin was the predominant prostanoid in both non-labouring and labouring myometria, with PGD(2) and PGF(2 alpha) being the second most abundant. Although the total amount of prostanoids was increased in the labouring tissue, PGE(2) and 13,14-dihydro-15-keto-PGE(2) were the only prostanoids to increase significantly at early and late labour (p