Urine-concentrating ability in the aging kidney.
Urine-concentrating ability in the aging kidney.
复制标题
老化肾脏的尿液浓缩能力。
DOI：
10.1126/sageke.2003.24.pe15
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Sands,JeffM
中科院分区：
文献类型：
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作者：
Sands,JeffM
衰老的哺乳动物肾脏的尿液浓缩能力下降。研究表明，随着年龄的增长，肾功能会发生各种变化，这或许可以解释尿液浓缩能力下降的原因。最近，编码许多水和溶质转运蛋白以及加压素受体的基因已被克隆，所有这些都与尿液浓度有关。因此，随着年龄的增长，导致尿液浓缩能力下降的分子机制现在可以被解读。在这篇文章中，我讨论了最近旨在描述衰老哺乳动物肾功能变化的实验。
Urine-concentrating ability is decreased in the aging mammalian kidney. Studies have revealed various changes in kidney function that occur with aging and may explain the reduced ability to concentrate urine. Recently, the genes encoding many of the water- and solute-transport proteins and the vasopressin receptor, all of which are involved in urine concentration, have been cloned. Therefore, the molecular mechanisms that cause the reduction in urine-concentrating ability with aging can now be deciphered. In this Perspective, I discuss recent experiments designed to characterize this change in kidney function in aging mammals.