Antibodies to spotted fever-group rickettsiae in dogs in North Carolina.
Antibodies to spotted fever-group rickettsiae in dogs in North Carolina.
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北卡罗来纳州狗身上发现斑点热群立克次体抗体。
DOI：
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发表时间：
1987
影响因子：
1
通讯作者：
M. Levy
中科院分区：
文献类型：
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作者：
Edward B. Breitschwerdt;D. Moncol;W. Corbett;J. Maccormack;Willy Burgdorfer;R. Ford;M. Levy
进行了一项血清流行病学调查，以确定北卡罗来纳州不同地理区域犬血清中与4种斑点热群（SFG）立克次体反应的抗体的流行率。从600只狗中获得血清样本，并使用微量免疫荧光法测定抗体滴度。数据分析（将立克次体滴度大于或等于1：64作为阳性结果的标准）高估了犬暴露于该立克次体的实际患病率。当通过同时考虑每只狗对所有4种立克次体抗原的血清学反应来分析数据时，暴露于R montana的患病率为15%，暴露于R rhipicephali的患病率为11%，暴露于R rickettsii的患病率为5%。未观察到明确暴露于贝氏立克次体，并且由于对2种或2种以上抗原的最高滴度相同，因此无法确定13%的犬的特异性激发立克次体。我们的数据表明，犬暴露于R rhipicephali是普遍的东部沿海地区，而暴露于R蒙大拿州发生统一的状态。立克次体暴露似乎在中部皮埃蒙特地区更为普遍，但在西部山区很少遇到。犬立克次氏体暴露的区域血清阳性率接近人类暴露。我们的研究结果支持了早期的建议，即狗可以作为环境哨兵，用于确定斑点热疫源地的地理流行率。
A seroepidemiologic survey was conducted to determine the prevalence of antibodies reactive with 4 spotted fever-group (SFG) rickettsiae in sera of dogs from various geographic regions in North Carolina. Serum specimens were obtained from 600 dogs, and antibody titers were determined, using microimmunofluorescence. Data analysis (setting as the criterion for a positive result, a Rickettsia rickettsii titer greater than or equal to 1:64) overestimated the actual prevalence of canine exposure to this rickettsia. When data were analyzed by considering each dog's serologic response to all 4 rickettsial antigens simultaneously, the prevalence rate for exposure to R montana was 15%, to R rhipicephali was 11%, and to R rickettsii was 5%. A definitive exposure to R bellii was not observed, and the identification of the specific inciting rickettsia could not be established for 13% of the dogs, because of identical highest titers to 2 or more antigens. Our data indicate that canine exposure to R rhipicephali is prevalent in the eastern coastal region, whereas exposure to R montana takes place uniformly throughout the state. Rickettsia rickettsii exposure appears to be more prevalent in the central Piedmont region, but rarely is encountered in the western mountains. Regional seroprevalence for canine R rickettsii exposure approximates that for human exposure. Our findings support earlier suggestions that dogs may serve as environmental sentinels for establishing the geographic prevalence of foci of spotted fever.