MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes.
MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes.
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DOI：
10.1016/j.molcel.2011.08.021
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发表时间：
2011-09-16
期刊：
影响因子：
16
通讯作者：
Bartel DP
中科院分区：
文献类型：
--
作者：
Rissland OS;Hong SJ;Bartel DP
The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or down-regulated in many types of cancers. Here we report the reciprocal relationship—that of the cell cycle controlling the miR-16 family. Levels of this family increase rapidly as cells are arrested in G0. Conversely, as cells are released from G0 arrest, levels of the miR-16 family rapidly decrease. Such rapid changes are made possible by the unusual instabilities of several family members. The repression mediated by the miR-16 family is sensitive to these cell cycle changes, which suggests that the rapid up-regulation of the miR-16 family reinforces cell cycle arrest in G0. Upon cell cycle re-entry, the rapid decay of several members allows levels of the family to decrease, alleviating repression of target genes and allowing proper resumption of the cell cycle.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
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DOI：
10.1016/j.bbrc.2010.08.046
发表时间：
2010-09-17
影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0811523106
发表时间：
2009-04-28
影响因子：
11.1
作者：
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影响因子：
64.5
作者：
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通讯作者：
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影响因子：
64.8
作者：
He, Lin;He, Xingyue;Hannon, Gregory J.
通讯作者：
Hannon, Gregory J.