Radiofrequency ablation for eradication of pulmonary tumor in rabbits
Radiofrequency ablation for eradication of pulmonary tumor in rabbits
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DOI：
10.1006/jsre.2001.6208
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发表时间：
2001-08-01
影响因子：
2.2
通讯作者：
Marchal, G
中科院分区：
文献类型：
--
作者：
Miao, Y;Ni, YC;Marchal, G
背景射频消融（RFA）已成为临床肿瘤手术的替代方案。本实验通过动物实验探讨射频消融治疗肺肿瘤的可行性。将18只兔VX 2肺种植瘤分为两组。A组（n = 12）采用冷头电极技术行RFA治疗。B组（n = 6）行假手术。通过生存率、磁共振成像（MRI）、死后微血管造影和组织学检查评价治疗效果。B组所有动物均于肿瘤植入后3个月内死亡。A组12只兔中有9只（75.0%）的肿瘤被清除，其中4只存活3个月以上，另5只处死时发现无活瘤。1只兔接受不完全肿瘤消融，2只兔发生局部肿瘤复发和/或肺转移。射频治疗组3个月存活率明显高于对照组（P < 0.01）。急性RFA病变的典型MRI表现由五个特征性同心区组成，分别对应于组织学上的中央针道（A区）、肿瘤凝固（B区）、肺实质凝固（C区）、外周出血（D区）和炎症层（E区）。结论。结论：射频消融技术可有效地切除兔肺肿瘤。MRI是评估肺肿瘤消融术的有用方法。(C)北京：科学出版社.
Background. Radiofrequency ablation (RFA) has emerged as an alternative for surgery in clinical oncology. This animal experiment was conducted to evaluate the feasibility of RFA in the treatment of pulmonary tumor.Methods. Eighteen rabbits with pulmonary implantation of VX2 tumors were divided into two groups. Group A (n = 12) was treated with RFA by using a cooled-tip electrode technique. Group B (n = 6) received sham operation. The therapeutic efficacy was evaluated by survival rate, magnetic resonance imaging (MRI), postmortem microangiography, and histology.Results. All animals in group B died within 3 months after tumor implantation. Tumor eradication was achieved in 9 of 12 rabbits (75.0%) in group A, of which 4 rabbits survived longer than 3 months free of disease and another 5 rabbits were found free of viable tumor when sacrificed. One rabbit was subjected to incomplete tumor ablation and two rabbits suffered from local tumor relapse and/or lung metastasis. The 3-month survival rate of RFA-treated rabbits was significantly higher (P < 0.01) than that of control rabbits. The typical MRI appearances of the acute RFA lesion consisted of five characteristic concentric zones, which corresponded to central needle track (zone A), tumor coagulation (zone B), pulmonary parenchyma coagulation (zone C), peripheral hemorrhage (zone D), and inflammatory layer (zone E) on histology.Conclusions. Eradication of pulmonary tumor could be achieved with current RFA technique in rabbits. MRI is a useful modality for assessment of lung tumor ablation. (C) 2001 Academic Press.