Colorectal cancer: Engineered colons for cancer research.
Colorectal cancer: Engineered colons for cancer research.
复制标题
DOI：
10.1038/nrgastro.2016.125
复制
发表时间：
2016-09-01
期刊：
影响因子：
--
通讯作者：
Dickson, Iain
中科院分区：
文献类型：
--
作者：
Dickson, Iain
用于临床转化基础癌症研究的实验动物模型常常受到适用性限制的阻碍。现在，一种用于研究结直肠癌（CRC）的离体模型已经被开发出来，以克服这些局限性，包括用含有结直肠癌重要突变的基因工程细胞对人类结肠组织进行再细胞化。该系统模拟了结直肠癌的病理生理进展，并能够识别新的癌症驱动基因。
Experimental animal models for clinically translating basic cancer research are often hindered by applicability limitations. Now, an ex vivo model for studying colorectal cancer (CRC) has been developed to overcome such limitations, involving the recellularization of human colonic tissue with genetically engineered cells containing important mutations for CRC. This system mimicked the pathophysiological progression of CRC and enabled the identification of novel cancer driver genes.