Evaluation of Chronic Kidney Disease Epidemiology Collaboration equation to estimate glomerular filtration rate in scleroderma patients
Evaluation of Chronic Kidney Disease Epidemiology Collaboration equation to estimate glomerular filtration rate in scleroderma patients
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DOI：
10.1093/rheumatology/kes049
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发表时间：
2012-08-01
期刊：
影响因子：
5.5
通讯作者：
Salsano, Felice
中科院分区：
文献类型：
--
作者：
Gigante, Antonietta;Rosato, Edoardo;Salsano, Felice
客观的。 SSc 的肾脏受累通常是亚临床的，并且会发展为慢性肾脏病 (CKD)，并伴有肾小球滤过率 (GFR) 缓慢恶化。本研究的目的是研究慢性肾脏病流行病学协作 (CKD-EPI) 与血清肌酐 (sCr) 在正常范围内的 SSc 患者组中测量的 GFR (mGFR) 的相关性。方法。 41 名硬皮病患者（37 名女性和 4 名男性）入组，中位年龄为 46 岁。 GFR 使用 Technetium-99 m DTPA (Tc-99 m DTPA) 进行测量。使用改良的 Cockroft-Gault 公式、肾病饮食的 4 变量和 7 变量改良 (MDRD) 以及 CKD-EPI 方程来估计 GFR (eGFR)。结果。 mGFR 显示中值为 84 毫升/分钟（范围 32.8-121.2 毫升/分钟）。 7 名患者 GFR 降低（< 60 ml/min），19 名患者 GFR 在 60-90 ml/min 内，15 名患者 GFR > 90 ml/min。结果显示，BSA 改良的 Cockroft-Gault 与 mGFR 之间存在轻度相关性（P > 0.05），与 4 变量 MDRD 具有轻度统计学显着相关性（P < 0.05），与 7 变量 MDRD 具有高度统计学显着性相关性（P = 0.01），但使用 CKD-EPI 获得了最大的相关性（P = 0.002）。未发现与年龄、病程或疾病子集相关。结论。对于 sCr 值正常的硬皮病患者，CKD-EPI 是评估 GFR 的有用公式。
Objective. Renal involvement in SSc is often subclinical and chronic kidney disease (CKD) develops, with slow worsening of glomerular filtration rate (GFR). The present investigation was undertaken in order to study how well the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) correlates with measured GFR (mGFR) in a group of SSc patients with serum creatinine (sCr) in the normal range.Methods. Forty-one scleroderma patients (37 females and 4 males) with a median age of 46 years were enrolled. GFR was measured using technetium-99 m DTPA (Tc-99 m DTPA). The modified Cockroft-Gault formula, 4- and 7-variable Modification of Diet in Renal Disease (MDRD) and CKD-EPI equations were used for estimated GFR (eGFR).Results. mGFR showed a median value of 84 ml/min (range 32.8-121.2 ml/min). Seven patients had reduced GFR (< 60 ml/min), 19 had GFR within 60-90 ml/min and 15 had GFR > 90 ml/min. The results showed mild correlation between the BSA-modified Cockroft-Gault and mGFR (P > 0.05), mild statistically significant correlation with 4-variable MDRD (P < 0.05), high statistically significant correlation with 7-variable MDRD (P = 0.01), but the greatest correlation was obtained using CKD-EPI (P = 0.002). No correlation with age, disease duration or subset of disease was found.Conclusions. In scleroderma patients with normal sCr value, CKD-EPI is a useful formula to assess GFR.