COLONY-STIMULATING FACTOR-PRODUCING TUMORS - PRODUCTION OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND INTERLEUKIN-6 IS SECONDARY TO INTERLEUKIN-1 PRODUCTION
COLONY-STIMULATING FACTOR-PRODUCING TUMORS - PRODUCTION OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND INTERLEUKIN-6 IS SECONDARY TO INTERLEUKIN-1 PRODUCTION
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DOI：
10.1016/0959-8049(94)00347-8
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发表时间：
1994-01-01
影响因子：
8.4
通讯作者：
NAKAO, K
中科院分区：
文献类型：
--
作者：
TSUYUOKA, R;TAKAHASHI, T;NAKAO, K
我们报道过，产生集落刺激因子（CSF）的肿瘤也分泌白细胞介素-1（IL-1）和IL-6。在本研究中，我们描述了 IL-1 在 CSF 产生中所起的作用。 IL-1 受体拮抗剂在产生 CSF 的人肺癌细胞系中抑制粒细胞 (G)-CSF 和 IL-6 的产生约 90%。使用抑制 IL-1 基因表达的氢化可的松也获得了类似的结果。相比之下，15 个不产生 CSF 的人肺癌细胞系没有显示出可检测到的 IL-1 产生，尽管其中 7 个细胞系被外源性 IL-1 α 诱导产生 G-CSF 和 IL-6。对 IL-1 α 作出反应的细胞系，包括产生 GSF 的细胞系，表达 IL-1 α 受体。这些结果表明，产生CSF的肿瘤可以通过其组成型IL-1产生、IL-1受体表达以及IL-1依赖性的G-CSF和IL-6过量产生来表征。此外，转录因子可能参与异常的IL-1α产生。
We have reported that tumours producing colony-stimulating factor (CSF) also secrete Interleukin-1 (IL-1) and IL-6. In the present study, we characterised the role played by IL-1 in CSF production. IL-1 receptor antagonist inhibited the production of granulocyte (G)-CSF and IL-6 by approximately 90% in CSF-producing human lung carcinoma cell lines. Similar results were obtained with hydrocortisone, which suppresses IL-1 gene expression. In contrast, 15 non-CSF-producing human lung carcinoma cell lines did not show detectable IL-1 production, although seven of them were induced to produce G-CSF and IL-6 by exogenous IL-1 alpha. Cell lines that responded to IL-1 alpha, including the GSF-producing lines, expressed receptors for IL-1 alpha. These results indicate that CSF-producing tumours can be characterised by their constitutive IL-1 production, IL-1 receptor expression and IL-1-dependent excess production of G-CSF and IL-6. Furthermore, transcription factor(s) may be involved in the abnormal IL-1 alpha production.