Upon Progestin Stimulation Progesterone Receptor Membrane Component-1 is Phosphorylated in Breast Cancer Cells and Binds to Estrogen Receptor α-Coregulators PHB1 and PHB2
Upon Progestin Stimulation Progesterone Receptor Membrane Component-1 is Phosphorylated in Breast Cancer Cells and Binds to Estrogen Receptor α-Coregulators PHB1 and PHB2
复制标题
孕激素刺激后，乳腺癌细胞中的孕激素受体膜成分 1 被磷酸化，并与雌激素受体 α 共调节因子 PHB1 和 PHB2 结合
DOI：
10.1055/s-0037-1606151
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发表时间：
2017
影响因子：
2.7
通讯作者：
Meier-Stiegen F
中科院分区：
文献类型：
--
作者：
Willibald M;Bayer G;Stahlhut V;Poschmann G;Stühler K;Seeger H;Niederacher D;Fehm T;Neubauer H;Meier-Stiegen F
使用雌激素和合成孕激素的更年期激素联合治疗与乳腺癌的风险增加有关。孕激素对乳腺细胞的影响是复杂的，目前还不完全清楚。在以往的体外和体内研究中，我们发现不同的孕激素可以促进孕激素受体膜组分-1(PGRMC1)高表达的MCF7乳腺癌细胞的增殖，揭示了PGRMC1在将膜启动的孕激素信号传递到细胞内的潜在作用。本研究旨在进一步探讨孕激素结合后PGRMC1的激活机制及其下游信号转导机制。
Combined menopausal hormone therapy, using estrogen and synthetic progestins, is associated with an increased risk of developing breast cancer. The effect of progestins on breast cells is complex and not fully understood yet. In previous in vitro and in vivo studies, we found different progestins to increase the proliferation of Progesterone Receptor Membrane Component-1 (PGRMC1)-overexpressing MCF7 breast cancer cells, revealing a potential role of PGRMC1 in forwarding membrane-initiated progestin signals into the cell. Aim of this study was to further investigate the activation mechanism and downstream signaling of PGRMC1 after progestin binding.