Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer.
Correlations between Tumor to Background Ratio on Breast-Specific Gamma Imaging and Prognostic Factors in Breast Cancer.
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DOI：
10.3346/jkms.2017.32.6.1031
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发表时间：
2017-06
影响因子：
4.5
通讯作者：
Chung MS
中科院分区：
文献类型：
--
作者：
Lee SJ;Choi YY;Kim C;Chung MS
本研究的目的是探讨乳腺特异性γ显像（BSGI）获得的肿瘤背景比（TBR）与乳腺癌预后因素之间的相关性。67例浸润性导管癌患者接受术前BSGI。根据乳腺成像报告和数据系统（BIRADS），对BSGI图像进行视觉评分，从1分到5分。根据以下预后因素比较从阳性BSGI图像获得的TBR结果：肿瘤大小;腋窝淋巴结转移;核分级（NG）;组织学分级（HG）;亚型; Ki-67;以及雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER 2）的表达谱。在67个图像中，60个被归类为阳性发现（敏感性89.6%）。TBR值与肿瘤大小≥ 2cm（P = 0.001）、腋淋巴结转移（P = 0.007）、高HG（P = 0.029）、PR阴性（P = 0.036）和Ki-67 ≥ 14%（P = 0.007）显著相关。管腔型A和非管腔型A亚型之间的TBR显示出显著差异（P = 0.007）。多因素分析显示，TBR与肿瘤大小≥ 2 cm、腋窝淋巴结转移和PR阴性状态高度相关（P分别为0.003、0.048和0.030）。BSGI的高TBR与乳腺癌的不良预后因素显著相关。Luminal A亚型是一种预后更好的乳腺癌亚型，与BSGI的低TBR相关。
The purpose of this study was to investigate the correlations between tumor-to-background ratio (TBR) obtained from breast-specific gamma imaging (BSGI) and the prognostic factors of breast cancer. Sixty-seven patients with invasive ductal carcinoma who underwent preoperative BSGI were enrolled. The BSGI images were visually scored from 1 to 5 according to a breast imaging reporting and data system (BIRADS). The TBR results obtained from positive BSGI images were compared according to the following prognostic factors: tumor size; axillary lymph node metastasis; nuclear grade (NG); histologic grade (HG); subtype; Ki-67; and the expression profile of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Among 67 images, 60 were classified as a positive finding (sensitivity 89.6%). A higher TBR value was significantly correlated with tumor size ≥ 2 cm (P = 0.001), axillary lymph node metastasis (P = 0.007), high HG (P = 0.029), negative PR status (P = 0.036), and Ki-67 ≥ 14% (P = 0.007). The TBR showed a significant difference between the luminal A and non-luminal A subtypes (P = 0.007). On multivariate analysis, TBR had a high correlation with tumor size ≥ 2 cm, axillary lymph node metastasis, and negative PR status (P = 0.003, 0.048, and 0.030, respectively). A high TBR on BSGI was significantly correlated with poor prognostic factors of breast cancer. Luminal A subtype, a breast cancer subtype with more favorable prognosis, was associated with a low TBR on BSGI.