Transplantation of multiple abdominal viscera.
Transplantation of multiple abdominal viscera.
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DOI：
10.1001/jama.1989.03420100085029
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发表时间：
1989-03
期刊：
影响因子：
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通讯作者：
T. Starzl;M. Rowe;S. Todo;R. Jaffe;A. Tzakis;A. Hoffman;C. Esquivel;K. Porter;R. Venkataramanan;L. Makowka;R. Duquesnoy
中科院分区：
文献类型：
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作者：
T. Starzl;M. Rowe;S. Todo;R. Jaffe;A. Tzakis;A. Hoffman;C. Esquivel;K. Porter;R. Venkataramanan;L. Makowka;R. Duquesnoy
两名患有短肠综合征和继发性肝功能衰竭的儿童接受了胃、小肠、结肠、胰腺和肝脏的内脏切除和整块移植。第一名患者在围手术期死亡，但第二名患者在死于EB病毒相关淋巴组织增生性疾病（导致胆道梗阻和致命性败血症）之前存活了6个多月。在长期存活的儿童中，从未有移植物排斥或移植物抗宿主病的证据。同种移植物的组成器官在整个193天的存活期内发挥功能并保持其形态完整性。
Two children with the short-gut syndrome and secondary liver failure were treated with evisceration and transplantation en bloc of the stomach, small intestine, colon, pancreas, and liver. The first patient died perioperatively, but the second lived for more than 6 months before dying of an Epstein-Barr virus-associated lymphoproliferative disorder that caused biliary obstruction and lethal sepsis. There was never evidence of graft rejection or of graft-vs-host disease in the long-surviving child. The constituent organs of the homograft functioned and maintained their morphological integrity throughout the 193 days of survival.