Dark Matter RNA: Existence, Function, and Controversy.
Dark Matter RNA: Existence, Function, and Controversy.
复制标题
DOI：
10.3389/fgene.2012.00060
复制
发表时间：
2012
影响因子：
3.7
通讯作者：
St Laurent G
中科院分区：
文献类型：
--
作者：
Kapranov P;St Laurent G
长期以来，围绕着97-98%不编码蛋白质的人类基因组的∼的谜团一直吸引着科学家的想象力。蛋白质编码的2-3%的基因组将97-98%的蛋白质作为进化道路上的乘客和中性“货物”携带，还是后者具有生物学功能？争论的一方，许多评论将基因组的非编码部分称为“自私的”或“垃圾的”DNA(奥格尔和克里克)，而另一方面，作者认为它包含了生物体发育的真实蓝图(Penman；Mattick，)，以及发育复杂性的机制。因此，这个问题可以毫不夸张地称为当今遗传学中最重要的问题。
The mysteries surrounding the ∼97–98% of the human genome that does not encode proteins have long captivated imagination of scientists. Does the protein-coding, 2–3% of the genome carry the 97–98% as a mere passenger and neutral “cargo” on the evolutionary path, or does the latter have biological function? On one side of the debate, many commentaries have referred to the non-coding portion of the genome as “selfish” or “junk” DNA (Orgel and Crick,), while on the other side, authors have argued that it contains the real blueprint for organismal development (Penman,; Mattick,), and the mechanisms of developmental complexity. Thus, this question could be referred to without much exaggeration as the most important issue in genetics today.