Mechanobiology of the aortic heart valve.
Mechanobiology of the aortic heart valve.
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DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
J. Butcher;C. Simmons;J. Warnock
中科院分区：
文献类型：
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作者：
J. Butcher;C. Simmons;J. Warnock
主动脉心脏瓣膜是一种复杂而精密的结构，在具有机械挑战性的环境中发挥作用。随着每个心动周期，血流在瓣膜组织上施加剪切应力、弯曲应力以及拉伸力和压缩力。这些力量决定了大量的生物反应，包括基因表达，蛋白质活化和细胞表型。因此，机械力可能影响瓣膜重塑或病理变化。了解心脏瓣膜的机械生物学是一项艰巨的任务。在此，一些最近的研究，增加了目前的知识内皮细胞和间质细胞与物理力的相互作用进行检查。此外，实验共培养模型的描述，正在开发，以进一步提高内皮细胞间质细胞相互作用的理解。最后，器官培养系统被用来研究心脏瓣膜生物学的手段，从而提供了一个补充的方法，在体内实验，进行了说明。
The aortic heart valve is a complex and sophisticated structure that functions in a mechanically challenging environment. With each cardiac cycle, blood flow exerts shear stresses, bending stress and tensile and compressive forces on the valve tissue. These forces determine a plethora of biological responses, including gene expression, protein activation and cell phenotype. Consequently, mechanical forces may influence valve remodeling or pathological changes. Understanding the mechanobiology of heart valves is a vast task. Herein, some of the recent studies that have increased current knowledge of endothelial and interstitial cell interactions with physical forces are examined. Additionally, experimental co-culture models are described that are being developed to further improve the understanding of endothelial-interstitial cell interactions. Finally, the means by which organ culture systems are being utilized to study heart valve biology, thereby providing a complementary approach to in vivo experimentation, are described.