Research Interests
Research Interests
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发表时间：
2002
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通讯作者：
Mathieu Roger
中科院分区：
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作者：
Mathieu Roger
干细胞自我更新和产生多个子细胞系的能力需要某些基因的表达、其他基因座的抑制和转录可塑性。还有很多人。在正常发育中，这种全基因组转录程序在一定程度上是由染色质结构调控的。打包?DNA与组蛋白的状态。神经发育和精神疾病的基因组研究揭示了许多染色质调节因子的突变。此外，染色质调节因子在脑肿瘤中经常发生突变或异常表达。
The ability of stem cells to self-renew and produce multiple daughter cell lineages requires the expression of certain sets of genes,repression of other loci, and transcriptional ?plasticity? of many others. In normal development, such genome-wide transcriptional programs are in part regulated by chromatin structure ? the ?packaged? state of DNA with histone proteins. Genomic studies of neurodevelopmental and psychiatric disorders have revealed mutations in many chromatin regulators. Furthermore, chromatin regulators are frequently mutated or aberrantly expressed in brain tumors.