A novel and simple formula to predict liver mass in porcine experimental models
A novel and simple formula to predict liver mass in porcine experimental models
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DOI：
10.1038/s41598-019-48781-2
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发表时间：
2019-08-28
影响因子：
4.6
通讯作者：
Fondevila, Constantino
中科院分区：
文献类型：
--
作者：
Martinez de la Maza, Lilia;Prado, Veronica;Fondevila, Constantino
肝脏手术的一个主要限制是留下足够大小和功能的残余肝脏。实验模型旨在研究这种情况下的肝损伤和再生过程，但缺乏准确计算动物模型中肝脏质量的公式。本研究旨在创建一种新颖且简单的公式来估计实验性肝脏手术方案中常用的猪种的天然肝脏质量。使用 200 头雄性断奶长白杂交猪的数据，使用多元线性回归分析来生成该公式。用作预测模型变量的临床特征是体重和长度。猪肝脏质量的最终计算公式如下：肝脏质量(g)=26.34232*体重(kg)-1.270629*长度(cm)+163.0076； R-2 = 0.7307。该猪肝脏质量公式使用简单，可能有助于使用具有相似特征的动物来评估主要肝切除术后肝脏质量恢复的研究。
A primary limitation in hepatic surgery is leaving a remnant liver of adequate size and function. Experimental models have been designed to study processes of liver injury and regeneration in this context, yet a formula to accurately calculate liver mass in an animal model is lacking. This study aims to create a novel and simple formula to estimate the mass of the native liver in a species of pigs commonly used in experimental liver surgery protocols. Using data from 200 male weanling Landrace-Large White hybrid pigs, multiple linear regression analysis is used to generate the formula. Clinical features used as variables for the predictive model are body mass and length. The final formula for pig liver mass is as follows: Liver mass (g) = 26.34232 * Body mass (kg) - 1.270629 * Length (cm) + 163.0076; R-2 = 0.7307. This formula for porcine liver mass is simple to use and may be helpful in studies using animals of similar characteristics to evaluate restoration of liver mass following major hepatectomy.