The search for IDDM susceptibility genes - The next generation
The search for IDDM susceptibility genes - The next generation
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DOI：
10.2337/diabetes.45.5.544
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发表时间：
1996-05-01
期刊：
影响因子：
7.7
通讯作者：
Gabbay, KH
中科院分区：
文献类型：
--
作者：
Owerbach, D;Gabbay, KH
人类染色体的两个区域，6p21染色体上的HLA区域和11p15染色体上的胰岛素基因区域，已经对IDDM易感基因的存在进行了超过10年的详细研究。最近的基因组研究表明IDDM可能存在许多其他易感基因。为了证明HLA和胰岛素基因区域中易感基因的联系和身份，长期的研究为理解基因组搜索发现的假定的额外IDDM易感基因的复杂性和时间过程提供了一个视角和背景。
Two human chromosomal regions, the HLA region on chromosome 6p21 and the insulin gene region on chromosome 11p15, have been investigated in detail for more than 10 years for the presence of IDDM susceptibility genes. Recent genome searches indicate the possible existence of many additional susceptibility genes in IDDM. The lengthy and protracted studies to prove the linkage and identity of the susceptibility genes in the HLA and insulin gene regions provide a perspective and background for understanding the complexities and time course for characterization of the putative additional IDDM susceptibility genes uncovered by genome searches.