Mismatch negativity indices of enhanced preattentive automatic processing in panic disorder as measured by a multi-feature paradigm
Mismatch negativity indices of enhanced preattentive automatic processing in panic disorder as measured by a multi-feature paradigm
复制标题
DOI：
10.1016/j.biopsycho.2015.01.006
复制
发表时间：
2015-02-01
影响因子：
2.6
通讯作者：
Liu, Yanhua
中科院分区：
文献类型：
--
作者：
Chang, Yi;Xu, Jing;Liu, Yanhua
恐慌症(PD)是一种精神障碍，以反复发作的恐慌症为特征，并担心随后会发生恐慌症。失配负性(MMN)被认为是前注意自动加工的相关因素。本研究的目的是用MMN测量帕金森病患者的注意前自动信息加工。受试者包括15名DSM-IV诊断为帕金森病的无药物患者和15名年龄匹配的健康志愿者。用事件相关电位研究MMN。该协议使用了一种多功能范例。对平均波幅和波峰潜伏期进行重复测量方差分析。帕金森病患者的声强和位置的MMN均显著高于健康受试者。强度-MMN的波幅与疾病严重程度之间也有显著相关性。这些数据提供了帕金森病患者异常注意前自动信息处理的证据。特别是，这种异常可能是帕金森病特有的。(C)2015爱思唯尔B.V.保留所有权利。
Panic disorder (PD) is a mental disorder characterized by recurrent panic attacks and worrying about having subsequent attacks. Mismatch negativity (MMN) has been established as a correlate of preattentive automatic processing. The aim of the present study is to investigate the preattentive automatic information processing in PD patients as measured by MMN. Subjects included 15 medication-free patients with a DSM-IV diagnosis of PD and 15 age-matched healthy volunteers. MMN was investigated using event-related potentials. The protocol used a multi-feature paradigm. Mean amplitudes and peak latencies were subjected to repeated-measures ANOVAs. PD patients showed a significantly increased MMN of sound intensity and location compared with healthy participants. The correlation between the amplitudes of intensity-MMN and disease severity was also significant. These data provide evidence of anomalous preattentive automatic information processing in PD patients. In particular, the abnormality may be specific for PD. (C) 2015 Elsevier B.V. All rights reserved.