Molecular design of photocurable liquid biodegradable copolymers. 1. Synthesis and photocuring characteristics
Molecular design of photocurable liquid biodegradable copolymers. 1. Synthesis and photocuring characteristics
复制标题
DOI：
10.1021/ma991404i
复制
发表时间：
2000-02-08
期刊：
影响因子：
5.5
通讯作者：
Arnold, SC
中科院分区：
文献类型：
--
作者：
Matsuda, T;Mizutani, M;Arnold, SC
以ε-己内酯（CL）和三亚甲基碳酸酯（TMC）为单体，以多元醇为引发剂，2-乙基己酸锡（II）为催化剂，以等摩尔的单体投料比进行开环共聚反应，然后在羟基末端进行香豆素衍生化，制备了可光固化的液体生物降解共聚物。这些液体共聚物（分子量范围从约2500至12 000），三-和四香豆素化的共聚物，通过紫外（UV）光照射交联。通过更高的香豆素官能度、更高的UV强度和减小液体膜前体的厚度来增强光固化。立体光刻制备的微结构表面在生物医学领域具有潜在的应用前景。
Photocurable liquid biodegradable copolymers were prepared by ring-opening copolymerization of epsilon-caprolactone (CL) and trimethylene carbonate (TMC) at an equimolar monomer feed ratio in the presence of a polyol as an initiator and tin(II) 2-ethylhexanoate as a catalyst, followed by subsequent coumarin derivatization at their hydroxyl terminus. These liquid copolymers (molecular weight range from approximately 2500 to 12 000), tri- and tetracoumarinated copolymers, were cross-linked by ultraviolet (UV) light irradiation. Photocuring was enhanced by higher coumarin functionality, higher UV intensity, and reducing the thickness of the liquid film precursor. Stereolithographically prepared microarchitectured surfaces were demonstrated for potential applications in biomedical fields.