Genesis of sleep bruxism: Motor and autonomic-cardiac interactions
Genesis of sleep bruxism: Motor and autonomic-cardiac interactions
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DOI：
10.1016/j.archoralbio.2006.11.017
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发表时间：
2007-04-01
影响因子：
3
通讯作者：
Sessle, Barry
中科院分区：
文献类型：
--
作者：
Lavigne, Gilles J.;Huynh, Nelly;Sessle, Barry
这是一篇简短的综述论文，提出了假说，以解释可能涉及睡眠磨牙症(SB)发生的机制。在人类中，SB是一种重复性睡眠运动障碍，主要特征是频率为1赫兹的节律性咀嚼肌肉活动(RMMA)和偶尔磨牙。直到最近，人们对RMMA和SB事件的触发机制还知之甚少。据报道，在轻度睡眠中，大多数SB发作都与短暂的心脏和大脑重新激活有关(S 3-15岁)，被称为“微觉醒”。我们发现，RMMA在与睡眠微唤醒相关的一系列事件中是次要的：心脏(自主交感神经活动增加)和大脑分别在舌骨上肌活动开始前的几分钟和几秒钟被激活，最后在闭合咬肌或颞肌的RMMA激活。在非人类灵长类动物的研究中，我们发现睡眠期间皮质-球通路的兴奋性受到抑制；与安静清醒状态相比，睡眠期间皮质咀嚼区(CMA)的皮质微刺激(ICMS)没有观察到节律性下巴运动(RJM)。上述结果表明，睡眠中RMMA和SB发作的开始受到脑干觉醒-网状上行系统短暂和短暂活动的影响，有助于自主神经-心脏和运动调节网络活动的增加。(C)2006爱思唯尔有限公司。保留所有权利。
d This is a short review paper presenting hypothesis to explain the mechanism that may be involved in the genesis of sleep bruxism (SB). In humans, SB is a repetitive sleep movement disorder mainly characterized by rhythmic masticatory muscle activity (RMMA) at a frequency of 1 Hz and by occasional tooth grinding. Until recently, the mechanism by which RMMA and SB episodes are triggered has been poorly understood. It is reported that during light sleep, most SB episodes are observed in relation to brief cardiac and brain reactivations (3-15 s) termed "micro- arousals". We showed that RMMA are secondary to a sequence of events in relation to sleep micro-arousals: the heart (increase in autonomic sympathetic activity) and brain are activated in the minutes and seconds, respectively, before the onset of activity in suprahyoid muscles and finally by RMMA in jaw closing masseter or temporalis muscles. In non-human primate study, we have shown that the excitability of cortico-bulbar pathways is depressed during sleep; no rhythmic jaw movements (RJM) are observed following intracortical microstimulation (ICMS) of cortical masticatory area (CMA) during sleep compared to the quiet awake state.The above results suggest that the onset of RMMA and SB episodes during sleep are under the influences of brief and transient activity of the brainstem arousal-reticular ascending system contributing to the increase of activity in autonomic-cardiac and motor modulatory networks. (c) 2006 Elsevier Ltd. All rights reserved.