Microtensile testing of collagen fibril for cardiovascular tissue engineering
Microtensile testing of collagen fibril for cardiovascular tissue engineering
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DOI：
10.1002/jbm.a.30387
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发表时间：
2005-08-01
影响因子：
4.9
通讯作者：
Yost, MJ
中科院分区：
文献类型：
--
作者：
Wang, XN;Li, XD;Yost, MJ
作为心脏组织工程的候选支架材料，I型胶原材料由于结构特征如原纤维排列方向和环境因素如紫外线（UV）照射的差异而显示出不同的机械性能。在这篇文章中，一维拉伸应力测试进行了与使用纳米级拉伸试验机上的四组I型胶原蛋白样品的原纤维方向和/或紫外线照射方面的区别。用原子力显微镜（AFM）研究胶原蛋白的表面结构。研究了纤维取向和紫外光辐照对其力学性能的影响。结合胶原蛋白结构、原纤维取向和紫外线照射产生的交联的分散来讨论机械性能和变形机制。(c)2005 Wiley Periodicals，Inc.
As a candidate scaffold material for cardiac tissue engineering, Type I collagen material shows different mechanical properties due to the differences in the structural features such as orientation of fibril alignment and the environmental factors such as ultraviolet (UV) irradiation. In this article one-dimensional tensile stress tests were performed with the use of a nanoscale tensile tester on four groups of Type I collagen samples that were differentiated in terms of fibril orientation and/or UV irradiation. The collagen surface structure was studied with the use of an atomic force microscope (AFM). Effects of fibril orientation and UV irradiation on their mechanical properties were investigated. The mechanical properties and deformation mechanisms are discussed in conjunction with collagen structure, fibril orientation, and dispersion of the generated crosslinking by UV irradiation. (c) 2005 Wiley Periodicals, Inc.