A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior.
A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior.
复制标题
酸性T细胞死亡相关基因-8（TDAG8）受体在抑郁样行为中的潜在作用。
DOI：
10.1016/j.physbeh.2015.03.012
复制
发表时间：
2015-10-15
影响因子：
2.9
通讯作者：
Sah R
中科院分区：
文献类型：
--
作者：
Vollmer LL;Schmeltzer SN;Ahlbrand R;Sah R
炎症已被认为与抑郁症的病理生理有关。T细胞死亡相关基因-8 （TDAG8）受体是一种在中枢神经系统和外周免疫细胞上表达的质子感应g蛋白偶联受体（GPCR）。先前的研究表明，TDAG8受体可以调节炎症，并在中枢神经系统（CNS）中产生促炎反应。鉴于抑郁和炎症之间的联系，本研究的目的是研究TDAG8在抑郁相关行为中的作用。TDAG8 （TDAG8−/−）缺失小鼠在强迫游泳试验（FST）和蔗糖偏好范式中进行了测试。与野生型TDAG8 （TDAG8+/+）小鼠相比，TDAG8缺乏导致FST的不动性显著减弱。这些差异不是由于TDAG8缺乏引起的运动活动的改变，因为TDAG8+/+和TDAG8−/−小鼠在家庭笼子或新环境中表现出相似的活动。与野生型小鼠相比，TDAG8−/−小鼠对蔗糖的消耗显著增加，但基因型之间对蔗糖的偏好没有显著差异。总的来说，我们的研究结果支持TDAG8受体参与与抑郁症相关的行为反应。需要进一步的研究来验证TDAG8作为连接炎症和抑郁的新靶点。
Inflammation has been suggested to contribute to the pathophysiology of depression. The T cell death associated gene-8 (TDAG8) receptor is a proton-sensing G-protein-coupled receptor (GPCR) expressed on immune cells in both the CNS and periphery. Previous work has shown modulation of inflammation by the TDAG8 receptor, with pro-inflammatory responses reported in the central nervous system (CNS). Given the link between depression and inflammation, the aim of the present study was to investigate the role of TDAG8 in depression relevant behaviors. Mice deficient in TDAG8 (TDAG8−/−) were tested in the forced swim test (FST) and sucrose preference paradigm. TDAG8 deficiency resulted in significant attenuation of immobility in the FST as compared to wild type TDAG8 (TDAG8+/+) mice. These differences were not due to alterations in motor activity evoked by TDAG8 deficiency as TDAG8+/+ and TDAG8−/− mice displayed similar activity in the home cage or in a novel context. TDAG8−/− mice showed significantly higher consumption of sucrose compared to wild type mice although sucrose preference was not significantly different between genotypes. Collectively, our results support the involvement of the TDAG8 receptor in behavioral response relevant to depression. Further investigation is required to validate TDAG8 as a novel target linking inflammation and depression.