Ulcerative facial and nasal dermatitis and stomatitis in cats associated with feline herpesvirus 1
Ulcerative facial and nasal dermatitis and stomatitis in cats associated with feline herpesvirus 1
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DOI：
10.1046/j.1365-3164.1999.00145.x
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发表时间：
1999-12-01
影响因子：
1.4
通讯作者：
Garber, RL
中科院分区：
文献类型：
--
作者：
Hargis, AM;Ginn, PE;Garber, RL
在9只猫中发现了鼻平面或面部毛发皮肤的溃疡性皮炎，与疱疹病毒相容的核内包涵体有关。临床上，病变呈溃疡性和结痂性，且常持续存在。第十猫局灶性增生性溃疡性口腔炎，也与核内包涵体。显微镜下观察到坏死和溃疡，伴有显著的嗜酸性炎症。在所有病例的表面或附件上皮内均观察到核内包涵体。从两只猫的皮肤超微结构检查发现病毒粒子形态与疱疹病毒兼容。对从新鲜冷冻或福尔马林固定的石蜡包埋活检样本中提取的DNA进行猫疱疹病毒1型特异性聚合酶链反应（PCR）和/或对从福尔马林固定的石蜡包埋活检样本中提取的DNA进行共有引物PCR和DNA测序来自七只猫的活检样本显示该病毒与猫疱疹病毒1型难以区分。PCR在8只猫中的一只中呈阴性。
Ulcerative dermatitis of the nasal planum or haired skin of the face, associated with intranuclear inclusion bodies compatible with herpesvirus, was identified in nine cats. Clinically, lesions were ulcerative and crusted, and often persistent. A tenth cat had focal proliferative ulcerative stomatitis, also associated with intranuclear inclusion bodies. Microscopically, there was necrosis and ulceration associated with prominent eosinophilic inflammation. Intranuclear inclusion bodies were noted in all cases, within the surface or adnexal epithelium. Ultrastructural examination of skin from two cats revealed virions morphologically compatible with a herpesvirus. Polymerase chain reaction (PCR) specific for feline herpesvirus 1 on DNA extracted from fresh-frozen or formalin-fixed paraffin-embedded biopsy samples and/or consensus primer PCR with DNA sequencing performed on DNA extracted from formalin-fixed paraffin-embedded biopsy samples from seven cats revealed that the virus was indistinguishable from feline herpesvirus 1. PCR was negative in one of eight cats tested.