Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term
Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term
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DOI：
10.1093/brain/124.1.60
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发表时间：
2001-01-01
期刊：
影响因子：
14.5
通讯作者：
Murray, RM
中科院分区：
文献类型：
--
作者：
Allin, M;Matsumoto, H;Murray, RM
怀孕33周前出生的人有脑损伤的风险，这有可能破坏随后的神经发育。因此，他们表现出神经运动体征和认知缺陷的发生率增加，这些症状在青春期仍然可以检测到。众所周知，小脑参与运动的协调和认知过程。因此，我们着手研究早产儿青少年的认知和运动障碍是否与小脑异常相关，这一点通过脑MRT扫描的体积分析来揭示。使用基于PC的Cavalieri程序在67名非常早产的青少年和50名年龄匹配的足月出生对照中手动确定整个小脑的体积。在1、4、8和14-15岁时进行认知和神经系统评估，作为早产受试者长期随访的一部分。早产儿的小脑体积与足月儿的对照组相比显著减小（P < 0.001）。在控制潜在混杂因素后，这种差异仍然存在。小脑体积和运动神经学体征之间没有关联。然而，小脑体积和几个认知测试分数之间有显着的关联，特别是韦氏儿童智力量表修订版，考夫曼评估电池的儿童和Schonnel阅读年龄。这提供了进一步的证据表明小脑参与认知，并表明小脑异常可能是早产儿中发现的一些认知缺陷的基础。
Individuals born before 33 weeks' gestation are at risk of brain lesions, which have the potential to disrupt subsequent 'neurodevelopment. As a result they manifest an increased incidence of neuromotor signs and cognitive deficits, which can still be detected in adolescence. The cerebellum is known to be involved in both the coordination of movement and in cognitive processes. We therefore set out to establish whether cognitive and motor impairments in adolescents born very pre-term are associated with abnormalities of the cerebellum as revealed by volumetric analysis of brain MRT scans. The volume of the whole cerebellum was determined manually using a PC-based Cavalieri procedure in 67 adolescents born very pre-term and 50 age-matched, full-term born controls. Cognitive and neurological assessments were performed at 1, 4, 8 and 14-15 years of age as part of the long-term follow-up of the pre term subjects. The preterm-born subjects had significantly reduced cerebellar volume compared with term-born controls (P < 0.001). This difference was still present after controlling for potential confounders. There was no association between cerebellar volume and motor neurological signs. However, there were significant associations between cerebellar volume and several cognitive test scores, in particular the Wechsler Intelligence Scale for Children-Revised, the Kaufman Assessment Battery for Children and the Schonnel reading age. This provides further evidence implicating the cerebellum in cognition and suggests that cerebellar abnormalities may underlie some of the cognitive deficits found in individuals born very pre-term.