Association between multimorbidity and mortality in a cohort of patients admitted to hospital with COVID-19 in Scotland.
Association between multimorbidity and mortality in a cohort of patients admitted to hospital with COVID-19 in Scotland.
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DOI：
10.1177/01410768211051715
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发表时间：
2022-01
影响因子：
17.3
通讯作者：
McCowan C
中科院分区：
文献类型：
--
作者：
Agrawal U;Azcoaga-Lorenzo A;Fagbamigbe AF;Vasileiou E;Henery P;Simpson CR;Stock SJ;Shah SA;Robertson C;Woolhouse M;Ritchie LD;Shiekh A;Harrison EM;Docherty AB;McCowan C
我们调查了COVID-19住院患者的多病与随后死亡风险之间的关系。我们还探讨了多重疾病的存在与个体由于特定条件的存在而需要保护之间的相互作用及其与死亡率的关系。我们创建了一个在大流行第一波（2020年2月28日至2020年9月22日）期间因COVID-19在苏格兰住院的患者队列。我们确定了患者入院时的多重发病水平，并使用logistic回归分析了COVID-19住院患者的多重发病与死亡风险之间的关系。苏格兰,英国。新冠肺炎住院患者。苏格兰国家死亡证明记录的死亡率，并在死亡证明上被编码为COVID-19或在COVID-19检测呈阳性后28天内死亡。因COVID-19入院的患者中，近58%患有多病。校正屏蔽组中年龄、性别、社会阶层和存在等混杂因素后，多病与死亡率显著相关（校正优势比1.48,95%CI 1.26-1.75）。多重疾病的存在和屏蔽患者名单中的存在与死亡率独立相关，但两者均存在没有倍增效应（校正优势比0.91,95%CI 0.64-1.29）。多重发病是因COVID-19住院患者死亡的独立危险因素。在制定预防政策时，可以优先考虑患有多种疾病的个体，例如，扩大对这一群体的屏蔽建议，并优先考虑他们接种疫苗。
We investigated the association between multimorbidity among patients hospitalised with COVID-19 and their subsequent risk of mortality. We also explored the interaction between the presence of multimorbidity and the requirement for an individual to shield due to the presence of specific conditions and its association with mortality. We created a cohort of patients hospitalised in Scotland due to COVID-19 during the first wave (between 28 February 2020 and 22 September 2020) of the pandemic. We identified the level of multimorbidity for the patient on admission and used logistic regression to analyse the association between multimorbidity and risk of mortality among patients hospitalised with COVID-19. Scotland, UK. Patients hospitalised due to COVID-19. Mortality as recorded on National Records of Scotland death certificate and being coded for COVID-19 on the death certificate or death within 28 days of a positive COVID-19 test. Almost 58% of patients admitted to the hospital due to COVID-19 had multimorbidity. Adjusting for confounding factors of age, sex, social class and presence in the shielding group, multimorbidity was significantly associated with mortality (adjusted odds ratio 1.48, 95%CI 1.26–1.75). The presence of multimorbidity and presence in the shielding patients list were independently associated with mortality but there was no multiplicative effect of having both (adjusted odds ratio 0.91, 95%CI 0.64–1.29). Multimorbidity is an independent risk factor of mortality among individuals who were hospitalised due to COVID-19. Individuals with multimorbidity could be prioritised when making preventive policies, for example, by expanding shielding advice to this group and prioritising them for vaccination.
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影响因子：
3.7
作者：
Rieg S;von Cube M;Kalbhenn J;Utzolino S;Pernice K;Bechet L;Baur J;Lang CN;Wagner D;Wolkewitz M;Kern WV;Biever P;COVID UKF Study Group
通讯作者：
COVID UKF Study Group
DOI：
10.1016/s0140-6736(21)00677-2
发表时间：
2021-05-01
期刊：
Lancet (London, England)
影响因子：
--
作者：
Vasileiou E;Simpson CR;Shi T;Kerr S;Agrawal U;Akbari A;Bedston S;Beggs J;Bradley D;Chuter A;de Lusignan S;Docherty AB;Ford D;Hobbs FR;Joy M;Katikireddi SV;Marple J;McCowan C;McGagh D;McMenamin J;Moore E;Murray JL;Pan J;Ritchie L;Shah SA;Stock S;Torabi F;Tsang RS;Wood R;Woolhouse M;Robertson C;Sheikh A
通讯作者：
Sheikh A
影响因子：
24.3
作者：
Guan, Wei-jie;Liang, Wen-hua;He, Jian-xing
通讯作者：
He, Jian-xing
影响因子：
3
作者：
Elixhauser, A;Steiner, C;Coffey, RN
通讯作者：
Coffey, RN
影响因子：
13.8
作者：
Ioannou GN;Locke E;Green P;Berry K;O'Hare AM;Shah JA;Crothers K;Eastment MC;Dominitz JA;Fan VS
通讯作者：
Fan VS