Spasticity causes a fundamental rearrangement of muscle-joint interaction
Spasticity causes a fundamental rearrangement of muscle-joint interaction
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DOI：
10.1002/mus.10036
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发表时间：
2002-02-01
期刊：
影响因子：
3.4
通讯作者：
Fridén, J
中科院分区：
文献类型：
--
作者：
Lieber, RL;Fridén, J
肌节长度测量尺侧腕屈肌（FCU）肌肉的严重痉挛性腕屈挛缩患者（n = 6），以及桡神经损伤和正常支配FCU的患者（n = 12）。与桡神经损伤患者的FCU肌肉（2.41 +/- 0.31 pm）相比，痉挛FCU肌肉在腕部完全屈曲时具有极长的肌节长度（3.48 +/- 0.44 pm）。在3例痉挛性腕关节屈曲挛缩患者中，测量了FCU肌节长度-关节角度关系的斜率，发现其基本正常（0.017 +/- 0.005 μ m/度，n = 3），这表明尽管肌节绝对长度发生了显著变化，但连续肌节数量（因此肌纤维长度）不变。这些结果表明，痉挛状态导致了正常肌肉-关节解剖关系的重大改变，而这一点在以前我们的知识中还没有被认识到。我们推测，结果是由肌纤维无法增加连续肌节的增长，或选择性损失FCU肌肉长度继发于中枢神经系统病变。(C)2002年John Wiley Sons，Inc.
Sarcomere length was measured in flexor carpi ulnaris (FCU) muscles from patients with severely spastic wrist flexion contractures (n = 6), as well as from patients with radial nerve injury and a normally innervated FCU (n = 12). Spastic FCU muscles had extremely long sarcomere lengths with the wrist fully flexed (3.48 +/- 0.44 pm) compared to the FCU muscles of patients with radial nerve injury (2.41 +/- 0.31 pm). In three of the patients with spastic wrist flexion contractures, the slope of the FCU sarcomere length-joint angle relationship was measured and found to be, essentially, normal (0.017 +/- 0.005 mum/degrees, n = 3) suggesting that serial sarcomere number (and therefore muscle fiber length) was unchanged in spite of the dramatic absolute sarcomere length change. These results indicate that spasticity results in a major alteration of normal muscle-joint anatomical relationships that has not previously been recognized to our knowledge. We hypothesize that the results are explained either by the inability of muscle fibers to add serial sarcomeres in response to growth, or the selective loss of FCU muscle length secondary to the central nervous system lesion. (C) 2002 John Wiley Sons, Inc.