Heritability of Obesity-related Phenotypes and Association with Adiponectin Gene Polymorphisms in the Chinese National Twin Registry
Heritability of Obesity-related Phenotypes and Association with Adiponectin Gene Polymorphisms in the Chinese National Twin Registry
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DOI：
10.1111/j.1469-1809.2010.00565.x
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发表时间：
2010-03-01
影响因子：
1.9
通讯作者：
Hu, Yong H.
中科院分区：
文献类型：
--
作者：
Lee, Juan;Chen, Li;Hu, Yong H.
本研究的目的是估计中国双生子肥胖相关表型的遗传度，并探讨脂联素基因+45T>；G和+276G>；T多态与这些指标的关系。2001年至2005年，通过中国双胞胎登记系统从两个城市招募了1260对双胞胎。对脂联素基因座上的两个SNP(+45T>；G和+276G>；T)进行了基因分型。用结构方程模型估计遗传力和最佳拟合方差分量模型。用广义估计方程(GEE)分析了所有双胞胎之间的规律性联系。用扫描电子显微镜对基因不一致的双生子(DZ)进行SIB传递/不平衡检验。体重指数(BMI)基于加性遗传、共同和独特环境(ACE)模型的遗传率为61%，基于加性遗传和独特环境(AE)模型的腰围(WC)和腰臀比(WHR)的遗传率分别为75%和61%。脂联素基因+45T>；G和+276G>；T等位基因与肥胖相关表型在所有双生子或DZ不协调双生子中均无关联。我们的双生子数据不支持脂联素基因+45T>；G和+276G>；T多态与肥胖相关表型的关联。为了更好地了解脂联素基因多态性在肥胖中的作用，还需要进一步的研究。
P>The purpose of this study was to estimate the heritability of obesity-related phenotypes and investigate the association of adiponectin gene polymorphisms +45T > G and +276G > T with these measures in Chinese twins. 1260 twin pairs were recruited from two cities through the Chinese National Twin Registry System from 2001 to 2005. Two SNPs at the adiponectin locus (+45T > G and +276G > T) were genotyped. Structural equation modeling (SEM) was used to estimate heritability and the best-fitting variance component model. The regular association among all twins was analysed with generalised estimating equations (GEE). Sib-transmission/disequilibrium test (TDT) within dizygotic (DZ) twin pairs discordant for their genotype was performed using SEM. Additive genetic, common and unique environmental (ACE) model-based heritability of body mass index (BMI) was 61%, while additive genetic and unique environmental (AE)-model-based heritability of waist circumference (WC) and waist-hip ratio (WHR) were 75% and 61%, respectively. There was no association of adiponectin gene +45T > G and +276G > T genotypes with obesity-related phenotypes in all twins or discordant DZ twins. Our twins data did not support that there was an association between adiponectin gene polymorphisms +45T > G and +276G > T and the obesity-related phenotypes. Further studies are required to better understand the role of adiponectin gene polymorphisms in obesity.