Effect of gamma interferon on resolution of murine chlamydial genital infection
Effect of gamma interferon on resolution of murine chlamydial genital infection
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DOI：
10.1128/iai.60.10.4427-4429.1992
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发表时间：
1992-10
影响因子：
3.1
通讯作者：
R. Rank;K. H. Ramsey;E. Pack;D. Williams
中科院分区：
文献类型：
--
作者：
R. Rank;K. H. Ramsey;E. Pack;D. Williams
采用小鼠肺炎沙眼衣原体感染生殖道的小鼠，用单克隆大鼠抗γ干扰素（抗ifn - γ）抗体治疗，观察ifn - γ是否参与了感染的消退。在两个实验中，抗ifn - γ抗体治疗导致感染明显延长。为了支持这些数据，对慢性感染的nu/nu小鼠被动给予重组ifn - γ能够使一些动物的感染得到解决。
Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-gamma) antibody to determine whether IFN-gamma participated in the resolution of the infection. In two experiments, anti-IFN-gamma antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-gamma to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals.