The inflammatory cellular feature in the peripheral blood of chronic subdural hematoma patients.
The inflammatory cellular feature in the peripheral blood of chronic subdural hematoma patients.
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DOI：
10.1002/jcla.24706
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发表时间：
2022-10
影响因子：
2.7
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中科院分区：
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慢性硬膜下血肿（CSDH）是神经外科常见病，发病率逐年上升。CSDH的吸收途径尚不清楚。炎症因子是否进入外周血并引起全身反应尚不清楚。我们筛选了105名CSDH患者和105名对照个体。收集并比较两组患者的临床特征和血常规结果。比较两组治疗前后血常规变化。由于年龄可能影响炎症标志物，因此进行了年龄分层分析。治疗前CSDH患者的白色血细胞计数、中性粒细胞绝对计数、中性粒细胞百分比、中性粒细胞-淋巴细胞计数比值（NLR）和血小板与淋巴细胞计数比值（PLR）均在正常范围内，但显著高于对照组（p < 0.001）。对照组淋巴细胞绝对计数和淋巴细胞百分率均高于患者组（P < 0.001）。不同年龄组患者的炎性细胞相似。患者治愈后，白色细胞计数、中性粒细胞绝对值和百分比下降（p <0. 05），而单核细胞数增加。CSDH在外周血中引起轻微的全身性炎症反应，表明血肿吸收存在非血液学途径。筛选CSDH患者和对照个体。收集并比较两组患者的临床特征和血常规结果。比较两组治疗前后血常规变化。由于年龄可能影响炎症标志物，因此进行了年龄分层分析。结果如下：CSDH患者的炎症细胞高于对照组，与年龄分层对比相似。患者治愈后炎症细胞减少。CSDH在外周血中引起轻微的全身性炎症反应，表明血肿吸收存在非血液学途径。
Chronic subdural hematoma (CSDH) is a common neurosurgical disease with an increasing incidence. The absorption route of CSDH is not clear. Whether inflammatory factors enter the peripheral blood and cause systemic reactions is unknown. We screened 105 CSDH patients and 105 control individuals. Their clinical characteristics and blood routine results were collected and compared. The blood routine changes of CSDH patients before and after treatment were compared. Age‐stratified analysis was performed due to age may affect the inflammatory markers. The white blood cell count, absolute neutrophil count, neutrophil percentage, neutrophil‐lymphocyte count ratio (NLR), and platelet to lymphocyte count ratio (PLR) of CSDH patients before treatment were within the normal range, while were significantly higher than the control individuals (p < 0.001). The absolute lymphocyte count and lymphocyte percentage of control individuals were higher than those of patients (p < 0.001). The inflammatory cells in patients of different age groups were similar. After the patient was cured, the white blood cell count, the absolute value and percentage of neutrophils decreased (p < 0.05), while the number of monocytes increased. CSDH caused slight systemic inflammatory responses in the peripheral blood, implying that there is a non‐hematologic route for the absorption of hematoma. CSDH patients and the control individuals were screened. Their clinical characteristics and blood routine results were collected and compared. The blood routine changes of CSDH patients before and after treatment were compared. Age‐stratified analysis was performed due to age may affect the inflammatory markers. The results are as follows: Inflammatory cells were higher in CSDH patients than in controls, similar to age‐stratified contrasts. Inflammatory cells decreased after the patient was cured. CSDH caused slight systemic inflammatory responses in the peripheral blood, implying that there is a non‐hematologic route for the absorption of hematoma.