Neurons in the rat ventral lateral preoptic area are essential for the warm-evoked inhibition of brown adipose tissue and shivering thermogenesis.
Neurons in the rat ventral lateral preoptic area are essential for the warm-evoked inhibition of brown adipose tissue and shivering thermogenesis.
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DOI：
10.1111/apha.13213
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Morrison SF
中科院分区：
文献类型：
--
作者：
Conceição EPS;Madden CJ;Morrison SF
确定外侧视前区 (vLPO) 腹侧神经元在中枢神经系统温度调节中的作用。采用体内电生理学和神经药理学方法评估 vLPO 中神经元对乌拉坦/氯醛糖麻醉大鼠棕色脂肪组织 (BAT) 产热和肌肉颤抖调节的贡献。针对内侧视前区 (MPA) 和 vLPO 的 NMDA 纳米注射抑制了冷诱发的 BAT 交感神经活动 (SNA)，降低了 BAT 温度 (TBAT)、呼出二氧化碳、平均动脉压 (MAP) 和心率。用蝇蕈醇或 AP5/CNQX 抑制 vLPO 神经元会引起 BAT SNA、TBAT 增加、心动过速和 MAP 小幅升高。 MPA 神经元的激活抑制了 vLPO 中 AP5/CNQX 引起的 BAT 生热作用。 vLPO 神经元对 BAT SNA 的抑制不需要对下丘脑背内侧 (DMH) 的 GABA 能输入，但 MPA 为 DMH 提供 GABA 能输入。 vLPO 神经元的激活抑制了中缝苍白核 (rRPa) 中 NMDA 引起的 BAT 生热作用，但在 rRPa 中荷包牡丹碱后则没有抑制作用。 vLPO 抑制引起的 BAT 生热依赖于 DMH 和 rRPa 的谷氨酸输入，但这些兴奋性输入并非来自 MnPO 神经元。 vLPO 中神经元的激活也会抑制寒冷和前列腺素引起的肌肉颤抖，并且 vLPO 抑制足以引起颤抖。 vLPO 包含温暖环境诱发的肌肉颤抖和 BAT 生热抑制所需的神经元，通过直接或间接从 vLPO 到 rRPa 的 GABA 能输入介导。
To determine the role of neurons in the ventral part of the lateral preoptic area (vLPO) in CNS thermoregulation. In vivo electrophysiological and neuropharmacological were used to evaluate the contribution of neurons in the vLPO to the regulation of brown adipose tissue (BAT) thermogenesis and muscle shivering in urethane/chloralose-anaesthetized rats. Nanoinjections of NMDA targeting the medial preoptic area (MPA) and the vLPO suppressed the cold-evoked BAT sympathetic activity (SNA), reduced the BAT temperature (TBAT), expired CO2, mean arterial pressure (MAP), and heart rate. Inhibition of vLPO neurons with muscimol or AP5/CNQX elicited increases in BAT SNA, TBAT, tachycardia, and small elevations in MAP. The BAT thermogenesis evoked by AP5/CNQX in vLPO was inhibited by the activation of MPA neurons. The inhibition of BAT SNA by vLPO neurons does not require a GABAergic input to dorsomedial hypothalamus (DMH), but MPA provides a GABAergic input to DMH. The activation of vLPO neurons inhibits the BAT thermogenesis evoked by NMDA in the rostral raphe pallidus (rRPa), but not that after bicuculline in rRPa. The BAT thermogenesis elicited by vLPO inhibition is dependent on glutamatergic inputs to DMH and rRPa, but these excitatory inputs do not arise from MnPO neurons. The activation of neurons in the vLPO also inhibits cold- and prostaglandin-evoked muscle shivering, and vLPO inhibition is sufficient to evoke shivering. The vLPO contains neurons that are required for the warm ambient-evoked inhibition of muscle shivering and of BAT thermogenesis, mediated through a direct or indirect GABAergic input to rRPa from vLPO.
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影响因子：
5.5
作者：
Nakamura, Kazuhiro;Morrison, Shaun F.
通讯作者：
Morrison, Shaun F.
影响因子：
3.3
作者：
Madden, CJ;Morrison, SF
通讯作者：
Morrison, SF
DOI：
10.1152/ajpregu.00427.2006
发表时间：
2007-01-01
影响因子：
2.8
作者：
Nakamura, Kazuhiro;Morrison, Shaun F.
通讯作者：
Morrison, Shaun F.
影响因子：
5.5
作者：
Nakamura, Kazuhiro;Morrison, Shaun F.
通讯作者：
Morrison, Shaun F.
影响因子：
2.9
作者：
Cao, WH;Morrison, SF
通讯作者：
Morrison, SF