Significance of vitamin D receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in Japanese
Significance of vitamin D receptor gene polymorphism for risk and disease severity of prostate cancer and benign prostatic hyperplasia in Japanese
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DOI：
10.1159/000058440
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发表时间：
2002-01-01
影响因子：
1.6
通讯作者：
Matsumoto, T
中科院分区：
文献类型：
--
作者：
Hamasaki, T;Inatomi, H;Matsumoto, T
目的：近年来研究表明维生素D受体（VDR）基因型与前列腺癌的发生有关。目前，关于VDR基因型与良性前列腺增生（BPH）相关性的数据很少。本研究的目的是调查日本前列腺癌患者、日本BPH患者和日本对照者中的Taql VDR多态性，以确定是否与E。VDR基因型与前列腺癌和BPH的发病风险以及疾病严重程度之间存在相关性。研究方法：对110例前列腺癌患者、83例BPH患者和90例年龄匹配的男性对照进行VDR基因外显子9第352位密码子的Taql限制性片段长度多态性基因分型。根据TaqI限制性位点的存在或不存在，将产物消化为T等位基因或t等位基因，将个体分类为TT、Tt或tt。结果如下：对照组中tt基因型的频率（6.7%）高于前列腺癌患者（1.8%）和BPH患者（3.6%），但无统计学意义。然而，与对照组相比，在具有局部晚期或转移性疾病（T3/T4/N1/M1）的前列腺癌患者中基因型TT的频率显著更高（p = 0.001）。此外，与对照组相比，具有高Gleason肿瘤分级（5级）的前列腺癌患者的基因型TT显着更高（p = 0.0001）。此外，与对照组相比，高前列腺体积（体积>50 cm（3））的BPH患者的TT基因型在统计学上更高（p = 0.001）。结论：这些数据表明，VDR基因型在确定日本男性更晚期和侵袭性前列腺癌以及前列腺肥大的风险方面起着重要作用。版权所有（C）2002 S. KargerAG，巴塞尔。
Objective: Recent studies have demonstrated an association between vitamin D receptor (VDR) genotype and prostate cancer. Currently, there is a scarcity of data regarding the association of VDR genotype with benign prostatic hyperplasia (BPH). The purpose of this study was to investigate the Taql VDR polymorphism in Japanese prostate cancer patients, Japanese BPH patients and Japanese controls in order to determine if an association E. exists between VDR genotype and the risk of developing prostate cancer and BPH as well as disease severity. Methods: 110 prostate cancer patients, 83 BPH patients and 90 male age-matched controls were geno-typed for a previously described Taql restriction fragment length polymorphism at codon 352 in exon 9 of the VDR gene. Products were digested into T allele or t allele according to the absence or presence of a TaqI restriction site with individuals being classified as TT, Tt or tt. Results: The frequency of the genotype tt was higher in the control group (6.7%) compared to patients with prostate cancer (1.8%) and BPH (3.6%) but this was not statistically significant. However, the frequency of the genotype TT was significantly higher among prostate cancer patients with locally advanced or metastatic disease (T3/T4/N1/M1) compared to controls (p = 0.001). In addition, the genotype TT was significantly higher among prostate cancer patients with a high Gleason grade of tumor (grade 5) compared to controls (p = 0.0001). In addition, the genotype TT was statistically higher in BPH patients with high prostate volume (volume >50 cm(3)) compared to controls (p = 0.001). Conclusion: These data demonstrate that VDR genotype plays an important role in determining the risk of more advanced and aggressive prostate cancer as well as prostatic enlargement in Japanese men. Copyright (C) 2002 S. KargerAG, Basel.