B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance
B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance
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宫颈癌中 B7-H3、B7-H4、Foxp3 和 IL-2 的表达：与患者预后和临床意义的关联
DOI：
10.3892/or.2016.4607
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发表时间：
2016-04-01
期刊：
影响因子：
4.2
通讯作者：
Zhang, Shulan
中科院分区：
文献类型：
--
作者：
Huang, Chenglin;Zhou, Lei;Zhang, Shulan
本研究旨在检测宫颈癌组织中B7-H3、B7-H4、Foxp3和IL-2的表达情况，并评价其临床意义。应用免疫组织化学方法检测108例宫颈癌标本中B7-H3、B7-H4、Foxp3和IL-2的表达，并探讨其与临床病理参数的关系。B7-H3、B7-H4和Foxp3在宫颈癌细胞中表达水平较高（分别为72.22%、80.56%和91.56%）。B7-H3水平仅与肿瘤大小相关（P=0.013），而B7-H4、Foxp3和IL-2水平与FIGO分期（P=0.023、0.014和0.036）和肿瘤大小相关（P=0.045、0.010和0.021）。其表达水平与年龄、组织学类型、分化程度及淋巴结转移无关（P < 0.05）。Cox回归多因素分析证实B7-H3或B7-H4过表达是独立的预后因素。B7-H3和B7-H4的表达与Foxp3呈显著正相关(P
The aim of this study was to determine the expression of B7-H3, B7-H4, Foxp3 and IL-2 in cervical cancer tissues, and evaluate the corresponding clinical significance. The expression of B7-H3, B7-H4, Foxp3 and IL-2 in 108 cervical cancer specimens was detected using immunohistochemistry, and their relationship with clinicopathologic parameters was determined. B7-H3, B7-H4 and Foxp3 had high levels of expression in cervical cancer cells (72.22, 80.56, and 91.56%, respectively). B7-H3 levels were only significantly associated with tumor size (P=0.013), while B7-H4, Foxp3 and IL-2 levels were significantly associated with International Federation of Gynecology and Obstetrics (FIGO) stage (P=0.023, 0.014 and 0.036, respectively) and tumor size (P=0.045, 0.010 and 0.021, respectively). Their expression levels were not correlated with age, histologic type, differentiation and lymph node metastasis (all P>0.05). Cox regression multivariate analysis confirmed that B7-H3 or B7-H4 overexpression was an independent prognostic factor. In addition, there were significant positive relationships between the expression of B7-H3 and B7-H4 with Foxp3 (P