Preeclampsia and breast cancer risk
Preeclampsia and breast cancer risk
复制标题
DOI：
10.1097/00001648-199911000-00013
复制
发表时间：
1999-11-01
期刊：
影响因子：
5.4
通讯作者：
Byers, TE
中科院分区：
文献类型：
--
作者：
Innes, KE;Byers, TE
乳腺癌与内源性激素水平有关，但确切的关系和潜在的机制尚不清楚。最近几项流行病学研究的数据表明，在自己怀孕期间经历先兆子痫的妇女，或者自己出生于先兆子痫妊娠的妇女，在以后的生活中患乳腺癌的风险降低。本文回顾了先兆子痫和乳腺癌风险之间联系的证据，并讨论了可能解释这种联系的激素机制。先兆子痫的特征是雌激素和胰岛素样生长因子-1水平降低，孕酮、雄激素、人绒毛膜促性腺激素、IGF-1结合蛋白、促肾上腺皮质激素释放因子、皮质醇和胰岛素水平升高。这些因素可以单独或协同作用，以降低乳腺癌的风险。妇女怀孕期间先兆子痫的发生可能反映了一种潜在的激素水平，这种激素水平既使她易患先兆子痫，又降低了她患乳腺癌的风险。此外，妊娠期间与先兆子痫相关的主要激素变化可能对随后的乳腺癌产生持久影响：风险。最后，子宫的激素和营养环境，先兆子痫是一个标志，可能在规划女性后代终身患乳腺癌的风险中发挥重要作用。
Breast cancer is associated with endogenous hormone levels, but the exact relation and underlying mechanisms remain unclear. Data from several recent epidemiologic studies suggest that a woman who experiences preeclampsia in her own pregnancy, or who was herself born to a preeclamptic pregnancy, is at reduced risk for breast cancer later in life. This paper reviews the evidence fora connection between preeclampsia and breast cancer risk, and discusses the hormonal mechanisms that might explain this association. Preeclampsia is characterized by reduced levels of estrogens and insulin-like growth factor-1, and by elevated levels of progesterone, androgens, human chorionic gonadotropin, IGF-1 binding protein, corticotropin-releasing factor, cortisol, and insulin. These factors may act both individually and synergistically to decrease breast cancer risk. The occurrence of preeclampsia during a woman's pregnancy may reflect an underlying hormonal profile that both predisposes her to preeclampsia and reduces her risk for breast cancer. In addition, the major hormonal alterations associated with preeclampsia during gestation may have lasting effects on subsequent breast cancer:risk. Finally, the hormonal and nutritional environment of the womb, for which preeclampsia is a marker, may play an important role in programming lifelong risk for breast cancer in the female offspring.