Evidence for polar positional information independent of cell division and nucleoid occlusion
Evidence for polar positional information independent of cell division and nucleoid occlusion
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DOI：
10.1073/pnas.0305747101
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发表时间：
2004-01-20
影响因子：
11.1
通讯作者：
Goldberg, MB
中科院分区：
文献类型：
--
作者：
Janakiraman, A;Goldberg, MB
我们提出的证据表明，在大肠杆菌中，极性位置信息存在于中细胞，与已知的细胞分裂因子无关。在丝状细胞中，ICSA通常是极性的，定位于潜在的细胞分裂位点或附近。由于细胞极来自隔膜，ICSA在细丝中定位的位置对应于未来的极。ICSA对这些部位的定位与FtsZ、MinCDE、间隔和核样闭塞无关，表明未来极点的位置信息与细胞分裂和染色体定位无关。当ICSA定位到这些位置时，分隔被抑制，这表明ICSA对这种极地位置信息的识别可能会影响细胞分裂。
We present evidence that, in Escherichia coli, polar positional information is present at midcell independent of known cell division factors. In filamented cells, IcsA, which is normally polar, localizes at or near potential cell division sites. Because the cell pole is derived from the septum, the sites to which IcsA localizes in filaments correspond to future poles. IcsA localization to these sites is independent of FtsZ, MinCDE, septation, and nucleoid occlusion, indicating that positional information for the future pole is independent of cell division and chromosome positioning. Upon IcsA localization to these sites, septation is inhibited, suggesting that IcsA recognition of this polar positional information may influence cell division.