Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation.

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation.
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炎症过程中Wnt/β-Catenin与NF-κB信号通路的相互作用

DOI:
10.3389/fimmu.2016.00378
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发表时间:
2016
影响因子:
7.3
通讯作者:
Hottiger MO
Hottiger MO
中科院分区:
医学2区
文献类型:
--
作者:
Ma B;Hottiger MO

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Besides its important role in embryonic development and homeostatic self-renewal in adult tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory functions. This is, at least partially, due to either repressing or enhancing the NF-κB pathway. Similarly, the NF-κB pathway either positively or negatively regulates Wnt/β-catenin signaling. Different components of the two pathways are involved in this crosstalk, forming a complex regulatory network. This review summarizes our current understanding of the molecular mechanisms underlying the cross-regulation between the two pathways and discusses their involvement in inflammation and inflammation-associated diseases such as cancer.
致癌性CARMA1夫妇在扩散的大B细胞淋巴瘤中NF-κB和β-catenin信号传导。
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