Improvement of renal diffusion-weighted magnetic resonance imaging with readout-segmented echo-planar imaging at 3 T
Improvement of renal diffusion-weighted magnetic resonance imaging with readout-segmented echo-planar imaging at 3 T
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DOI：
10.1016/j.mri.2015.02.023
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发表时间：
2015-07-01
影响因子：
2.5
通讯作者：
Vallee, Jean-Paul
中科院分区：
文献类型：
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作者：
Friedli, Iris;Crowe, Lindsey A.;Vallee, Jean-Paul
目的：通过与单次激发SE-EPI(ss-EPI)比较，评价呼吸门控读出分段SE-EPI(RESOLE)用于肾脏弥散加权成像的可行性。材料与方法：对充液体模、20例健康志愿者和10例慢性肾脏疾病患者，在3T磁共振系统上，采用3个DW序列(b值分别为0、300、500、900 S/mm(2))，扫描参数和线圈相同。标准SS-EPI(参考EPI)，具有更高分辨率、带宽和加速因子(HR-EPI)的SS-EPI，分辨率与HR-EN相同，但将读数分割为5个镜头。使用单因素方差分析(ANOVA)和自组织后Bonferroni(p<；0.05为统计学意义)比较3个序列之间的几何失真、基于Canny边缘检测的图像模糊、b(O)图像上测量的皮质-髓质分化和ADC量化(p<；0.05为统计学意义)。结果：在志愿者和患者中，RESOLE显著减少了几何失真和模糊，并改善了清晰度评分，与ss-EPI相比，平均提高了56%(p=0.02)。在健康志愿者中，皮质和髓质的ADC值分别为1994年的+/-246和1762+/-238(p<；0.001)，在更大的b值范围内(p<；0.02)，皮质和髓质的ADC值(在10(-6)mm(2)/S)上也是可能的。在慢性肾脏病患者中，RESOLE序列的ADC值(10-6 mm(2)/S)在皮质(1755+/-145)和髓质(1799+/-163)之间没有差异。结论：尽管扫描时间较长，但RESOLE通过改善正常志愿者肾皮质和髓质的SI和ADC值的差异，显著提高了肾脏弥散加权图像的质量。在CKD患者中，RESOLE显示这种皮质-髓质ADC值的差异消失。这些改进证明了进一步的临床研究是合理的。(C)2015 Elsevier Inc.保留所有权利。
Purpose: To assess the feasibility of a respiratory-gated implementation of readout-segmented SE-EPI (RESOLVE) for renal diffusion-weighted imaging (DWI) by comparison with single-shot SE-EPI (ss-EPI) in a phantom, healthy volunteers and chronic kidney disease (CKD) patients.Materials and Methods: A fluid-filled phantom, 20 healthy volunteers and 10 CKD patients were scanned with the same parameters and coils on a 3 T MR system with 3 DW sequences (b-values = 0, 300, 500, 900 s/mm(2)). a standard ss-EPI (Reference EPI), a ss-EPI with higher resolution, bandwidth and acceleration factor (HR-EPI) and RESOLVE with the same spatial resolution as HR-EN but a segmentation of the readout into 5 shots. Geometric distortions, image blurring using a 'Canny' edge detection based measure, cortico-medullary differentiation measured on b(o) images and ADC quantification were compared between the 3 sequences using one-way analysis of variance (ANOVA) with post-hoc Bonferroni (p < 0.05 was talcen as statistically significant).Results: RESOLVE reduced significantly geometric distortions and blurring and improved, in the volunteers and patients, the sharpness score by 56% on average in comparison to ss-EPI (p = 0.02). In healthy volunteers, the cortico-medullary differentiation with RESOLVE was also possible on a wider range of b-values (p < 0.02) with ADC values (in 10(-6) mm(2)/s) of 1994 +/- 246 in the cortex and 1762 +/- 238 in the medulla (p < 0.001). In CKD patients, ADC values (in 10-6 mm(2)/s) from the RESOLVE sequence were not different between the cortex (1755 +/- 145) and the medulla (1799 +/- 163, p = 0.49).Conclusion: Despite a longer scan time, RESOLVE enhanced significantly the quality of renal diffusion-weighted images by improving the difference in SI and ADC between the renal cortex and medulla in healthy volunteers. In CKD patients, RESOLVE showed a disappearance of this cortico-medullary ADC difference. These improvements justify further clinical studies. (C) 2015 Elsevier Inc. All rights reserved.