Measurement of both left ventricular function and regional myocardial perfusion with 133Xe in dogs.
Measurement of both left ventricular function and regional myocardial perfusion with 133Xe in dogs.
复制标题
用 133Xe 测量狗的左心室功能和局部心肌灌注。
DOI：
10.1007/bf00296092
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Boucher,CA
中科院分区：
文献类型：
--
作者：
Ruddy,TD;Yasuda,T;Barlai-Kovach,M;Nedelman,MA;Moore,RH;Alpert,NM;Correia,JA;Newell,JB;Okada,RD;Boucher,CA
在12只狗中验证了测量左心室（LV）功能和心肌灌注的技术。将133 μ mol/L生理盐水注入左心房（LA）或LV，并使用伽马相机成像获得两个数据集：1）LV功能的首过门控扫描;其次是2）局部心肌灌注的序列图像。133 mTc心血池显像测定的左室射血分数和室壁运动与99 mTc心血池显像测定的射血分数和室壁运动比较，二者相关系数分别为0.88，0.83，P <0.01。133氚法测定的灌注值与微球法测定的灌注值比较，相关系数r= 0.79，P <0.01。LV 133 β注射后的测量结果与LA注射后的数据相似。因此，通过LA或LV 133 β注射和γ照相机成像，可以定量评估整体LV功能、局部室壁运动和心肌灌注。
A technique to measure left ventricular (LV) function and myocardial perfusion was validated in 12 dogs.133Xe in saline was injected into the left atrium (LA) or LV and two data sets were obtained using gamma camera imaging: 1) A first pass gated scan for LV function; followed by 2) Sequential images for regional myocardial perfusion. LV ejection fraction and wall motion measurements from the133Xe blood pool images were compared to ejection fraction (r=0.88,P<0.01) and wall motion (r=0.83,P<0.01) data from99mTc labeled blood pool scans. The perfusion measurements obtained with the133Xe method were compared to microsphere data (r=0.79,P<0.01). Measurements after LV133Xe injection were similar to data following LA injection. Thus, quantitative assessment of global LV function, regional wall motion and myocardial perfusion is possible with LA or LV133Xe injection and gamma camera imaging.