Rapid turnover of T lymphocytes in SIV-infected rhesus macaques
Rapid turnover of T lymphocytes in SIV-infected rhesus macaques
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DOI：
10.1126/science.279.5354.1223
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发表时间：
1998-02-20
期刊：
影响因子：
56.9
通讯作者：
Ho, DD
中科院分区：
文献类型：
--
作者：
Mohri, H;Bonhoeffer, S;Ho, DD
动物模型中淋巴细胞周转的研究对于理解人类免疫缺陷病毒感染中细胞杀伤的机制和淋巴细胞再生的程度具有重要意义。定量分析CD4和CD8 T淋巴细胞的溴脱氧尿苷标记的序列变化不仅揭示了这些细胞群在未感染猕猴体内的正常增殖和死亡率，而且还显示了这些细胞群在猴免疫缺陷病毒（SIV）感染后的增殖和死亡率大幅增加。在受感染的猕猴中，还观察到记忆和幼稚T淋巴细胞亚群以及NK（自然杀手）和B细胞中更快的标记和去标记，这表明SIV诱导了一种普遍激活状态。
Studies of lymphocyte turnover in animal models have implications for understanding the mechanism of cell killing and the extent of lymphocyte regeneration in human immunodeficiency virus infection. Quantitative analyses of the sequential changes in bromodeoxyuridine labeling of CD4 and CD8 T lymphocytes not only revealed the normal proliferation and death rates of these cell populations in uninfected macaques, but also showed a substantial increase in these rates associated with simian immunodeficiency virus (SIV) infection. Faster labeling and delabeling in memory and naive T lymphocyte subpopulations as well as in NK (natural killer) and B cells were also observed in infected macaques, suggesting a state of generalized activation induced by SIV.