Simulation of voltage-driven hydrated cation transport through narrow transmembrane channels.
Simulation of voltage-driven hydrated cation transport through narrow transmembrane channels.
复制标题
模拟电压驱动的水合阳离子通过狭窄跨膜通道的传输。
DOI：
10.1016/s0006-3495(87)83425-2
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发表时间：
1987
影响因子：
3.4
通讯作者：
J. Brickmann
中科院分区：
文献类型：
--
作者：
A. Skerra;J. Brickmann
提出了碱金属离子锂、钠和钾通过充满水分子的短杆菌肽 A 型通道的电压驱动传输的分子动力学研究。通道中水分子的数量是从先前的研究中获得的（Skerra, A., 和 J. Brickmann, 1987, Biophys. J., 51:969–976）。结果表明，通道内离子扩散通过模型孔的选择性与实验观察到的短杆菌肽 A 通道的选择性一致。结果表明，通道中水分子的数量对于选择性起着关键作用。
Molecular dynamics studies for the voltage-driven transport of the alkali metal ions lithium, sodium, and potassium through gramicidin A-type channels filled with water molecules are presented. The number of water molecules in the channel is obtained from a previous study (Skerra, A., and J. Brickmann, 1987, Biophys. J., 51:969–976). It is shown that the selectivity of the intrachannel ion diffusion through our model pore conforms to the experimentally observed selectivity of the gramicidin A channel. It is demonstrated that the number of water molecules in the channel plays a key role for the selectivity.