Pharmacogenomics of cisplatin-induced ototoxicity.
Pharmacogenomics of cisplatin-induced ototoxicity.
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DOI：
10.2217/pgs.11.48
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发表时间：
2011-07
期刊：
影响因子：
2.1
通讯作者：
Rybak LP
中科院分区：
文献类型：
--
作者：
Mukherjea D;Rybak LP
顺铂耳毒性对不同个体的影响差异很大。这些变异很可能可以用受影响人群的基因差异来解释。鉴定易患顺铂耳毒性的遗传变异将是非常有利的，以便将易感亚群的风险降至最低。尽管这一领域的研究非常重要，但只有少数研究严格检查了顺铂诱导的听力损失易感性的遗传基础。本文阐述了顺铂耳毒性发生率和危险因素的最新进展，以及与顺铂致听力损失相关的遗传变异鉴定的争议。
Cisplatin ototoxicity affects different individuals in a widely variable manner. These variations are likely to be explained by genetic differences among those affected. It would be highly advantageous to identify genetic variants that predispose to cisplatin ototoxicity in order to minimize the risk to susceptible subgroups. Although this area of research is very important, only a few studies have rigorously examined the genetic basis for cisplatin-induced susceptibility to hearing loss. This article addresses recent progress in clarifying the incidence of cisplatin ototoxicity and the risk factors and controversies regarding the identifcation of genetic variants associated with cisplatin-induced hearing loss.