Preferred conformations of peptides containing α,α‐disubstituted α‐amino acids
Preferred conformations of peptides containing α,α‐disubstituted α‐amino acids
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含有α,α-二取代的α-氨基酸的肽的优选构象
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
C. Pedone
中科院分区：
文献类型：
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作者：
C. Toniolo;G. Bonora;A. Bavoso;E. Benedetti;B. di Blasio;V. Pavone;C. Pedone
从28个化合物的晶体结构出发，综述了含有α，α-二取代α-氨基酸的线型多肽的构象选择。特别强调了多肽构象对这些不寻常氨基酸几何构象的敏感性。我们还考虑了未来可能的研究方向，我们希望这将导致对Peptaibol抗生素所采用的结构的全面了解。
The conformational preferences of linear peptides containing α,α‐disubstituted α‐amino acids, derived from the crystal structures of 28 compounds, are reviewed. In particular, the sensitivity of peptide conformation to the geometry of these unusual amino acids is underlined. We also consider possible future directions of research, which, we hope, will result in a complete understanding of the structures adopted by peptaibol antibiotics.