Changes in the plasma aminogram of parenterally fed infants treated with dexamethasone for bronchopulmonary dysplasia.
Changes in the plasma aminogram of parenterally fed infants treated with dexamethasone for bronchopulmonary dysplasia.
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用地塞米松治疗支气管肺发育不良的肠外喂养婴儿的血浆氨基酸图的变化。
DOI：
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发表时间：
1992
影响因子：
5.2
通讯作者：
P. Dear
中科院分区：
文献类型：
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作者：
Pak Cheung Ng;K. G. Brownlee;E. J. Kelly;M. J. Henderson;M. Smith;P. Dear
在59名患有慢性肺病的早产儿中，在开始地塞米松治疗后不久，观察到大多数氨基酸的血浆浓度大幅增加。增加的幅度似乎与剂量相关。这种现象可能是类固醇诱导的蛋白质催化作用的结果。有趣的是，苯丙氨酸和酪氨酸浓度均未显著增加。
A substantial increase in the plasma concentration of most amino acids was observed in 59 preterm infants with chronic lung disease soon after the initiation of dexamethasone therapy. The size of increase appeared to be dose related. This phenomenon is likely to be the result of steroid induced protein catabolism. Interestingly, neither phenylalanine nor tyrosine concentrations were significantly increased.