BENZODIAZEPINE OVERDOSAGE - PLASMA-CONCENTRATIONS AND CLINICAL OUTCOME
BENZODIAZEPINE OVERDOSAGE - PLASMA-CONCENTRATIONS AND CLINICAL OUTCOME
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DOI：
10.1007/bf00426470
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发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
SHADER, RI
中科院分区：
文献类型：
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作者：
DIVOLL, M;GREENBLATT, DJ;SHADER, RI
对21例急性过量服用苯二氮卓类药物后到达紧急治疗设施的患者的血浆浓度及其与临床结果的关系进行了评估。21例中有18例涉及地西泮，血浆地西泮水平为585-8635 ng/ml。在4例单独使用地西泮过量的病例中，尽管地西泮剂量高达750 mg，血药浓度高达4792 ng/ml，但患者仍在24 h内进行了最低程度的镇静并出院。其余14例患者中有5例同时服用安定与其他中枢抑制药物（如乙醇、巴比妥类药物、镇痛药或三环类抗抑郁药）导致严重中毒，无论安定的剂量或血浆浓度如何。苯二氮卓类药物过量后中毒的严重程度主要取决于是否同时摄入其他中枢抑制剂，而不是苯二氮卓类药物的摄入量或其在血浆中的浓度。
Plasma concentrations and their relation to clinical outcome were evaluated in 21 patients who reached emergency treatment facilities following acute overdosage with benzodiazepine derivatives. Diazepam was implicated in 18 of the 21 cases, with plasma diazepam levels ranging from 585-8635 ng/ml. In 4 cases of overdosage with diazepam alone, patients were minimally sedated and were discharged within 24 h, despite diazepam doses as high as 750 mg and plasma levels as high as 4792 ng/ml. Concurrent ingestion of diazepam together with other central depressant drugs (such as ethanol, barbiturates, analgesics or tricyclic antidepressants) produced serious intoxication in 5 of the remaining 14 patients, regardless of the diazepam dosage or plasma concentration. The severity of poisoning following benzodiazepine overdosage is determined largely by coingestion of other central depressants rather than the amount of benzodiazepine ingested or its concentration in plasma.