Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease
Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease
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DOI：
10.1186/1475-2840-12-105
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发表时间：
2013-07-17
影响因子：
9.3
通讯作者：
Yang, Wei-Shiung
中科院分区：
文献类型：
--
作者：
Huang, Chi-Lun;Wu, Yen-Wen;Yang, Wei-Shiung
工作背景：脂肪细胞脂肪酸结合蛋白（A-FABP）等脂肪因子参与了动脉粥样硬化的发病过程。在本研究中，我们探讨了相关的循环A-FABP水平与心肌灌注异常的严重程度进行了分析，通过Tl-201潘生丁单光子发射计算机断层扫描。方法：共170例冠心病（CAD）患者从心血管门诊参加了这项研究。结果：与轻度CAD患者（总分[SSS] 8分）相比，轻度CAD患者A-FABP浓度明显升高。然而，在心力衰竭患者亚组中，差异减弱。相关性分析中，A-FABP水平与年龄、体重指数、腰围、肌酐水平、空腹血糖、高敏C反应蛋白、N末端脑钠肽前体、脂联素和几个超声心动图参数（包括左心室射血分数）相关。多因素Logistic回归分析显示，A-FABP水平不仅与较高的SSS相关，（比值比，1.30; 95%置信区间[CI]，1.01-1.69; P = 0.048），而且是心力衰竭的独立危险因素结论：冠心病患者血清A-FABP水平不仅与心肌灌注异常和左室功能有关，而且可预测心力衰竭的发生。
Background: Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circulating A-FABP level with severity of myocardial perfusion abnormalities analyzed by Tl-201 dipyridamole single-photon emission computed tomography.Methods: A total of 170 patients with coronary artery disease (CAD) from cardiovascular clinics were enrolled in the study. Serum A-FABP levels, echocardiography, and stress myocardial perfusion imaging results were analyzed.Results: Compared with the patients with mild CAD (summed stress score [SSS] 8) had significantly higher A-FABP concentrations. However, the difference was attenuated in the subgroup of patients with heart failure. In the correlation analyses, A-FABP level was correlated with age, body mass index, waist circumference, levels of creatinine, fasting glucose, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, adiponectin, and several echocardiographic parameters, including left ventricular ejection fraction. Multivariate logistic regression analysis demonstrated that the A-FABP level was not only associated with higher SSS (odds ratio, 1.30; 95% confidence interval [CI], 1.01-1.69; P = 0.048), but also an independent risk factor for heart failure (odds ratio 2.71, 95% CI, 1.23-5.94; P = 0.013).Conclusions: Serum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD.