The Canine Orthopedic Index. Step 3: Responsiveness Testing
The Canine Orthopedic Index. Step 3: Responsiveness Testing
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DOI：
10.1111/j.1532-950x.2014.12162.x
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发表时间：
2014-03-01
影响因子：
1.8
通讯作者：
Brown, Dorothy Cimino
中科院分区：
文献类型：
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作者：
Brown, Dorothy Cimino
目的确定犬骨科指数 (COI) 是否可以检测用非甾体抗炎药 (NSAID) 或安慰剂治疗的骨关节炎 (OA) 狗的变化。研究设计双盲随机安慰剂对照试验。患有 OA 的动物狗 (n = 80)。方法主人在第 0 天完成 COI。狗在第 1 天到第 14 天服用卡洛芬或安慰剂。主人完成了第 14 天再次进行 COI。评估各组之间总仪器评分、僵硬度、步态、功能和生活质量评分的变化。结果与接受安慰剂治疗的狗相比，给予卡洛芬的狗的总仪器评分 (P = .002) 以及 4 个因子评分中的 3 个评分显着下降（僵硬评分 P = .015；步态评分 P = .001；功能评分 = 0.008）。卡洛芬治疗犬和安慰剂治疗犬之间生活质量评分的变化没有显着差异（P = .124）。结论与安慰剂治疗相比，COI 使接受 NSAID 治疗的 OA 犬的总器械、僵硬、步态和功能评分有所下降，这符合人们的预期。在这组狗中，生活质量评分对与 NSAID 给药相关的变化不敏感。
ObjectiveTo determine whether the Canine Orthopedic Index (COI) can detect changes in dogs with osteoarthritis (OA) treated with either non-steroidal anti-inflammatory drugs (NSAID) or placebo.Study DesignDouble blind randomized placebo controlled trial.AnimalsDogs (n = 80) with OA.MethodsOwners completed the COI on Day 0. Dogs were administered either carprofen or placebo on days 1 through 14. Owners completed the COI again on Day 14. The change in total instrument, stiffness, gait, function, and quality of life scores were assessed between groups.ResultsDogs administered carprofen had significant decreases in the total instrument score (P = .002) as well as 3 of the 4 factor scores compared to dogs treated with placebo (stiffness score P = .015; gait score P = .001; and function score = 0.008). The change in quality of life score was not significantly different between carprofen and placebo treated dogs (P = .124).ConclusionsThe COI delivered the decreases in total instrument, stiffness, gait, and function scores that one would expect in dogs with OA treated with an NSAID compared with placebo administration. In this cohort of dogs, the quality of life score was not sensitive to the changes associated with NSAID administration.