Effects of caveolin-1 on the 17β-estradiol-mediated inhibition of VSMC proliferation induced by vascular injury
Effects of caveolin-1 on the 17β-estradiol-mediated inhibition of VSMC proliferation induced by vascular injury
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DOI：
10.1016/j.lfs.2006.11.014
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发表时间：
2007-01-30
期刊：
影响因子：
6.1
通讯作者：
Wang, Ting-Huai
中科院分区：
文献类型：
--
作者：
Liu, Hai-Mei;Zhao, Xiao-Feng;Wang, Ting-Huai
Estrogen has a protective effect on the cardiovascular system. Yet the mechanism of how estrogen inhibits vascular smooth muscle cell (VSMC) proliferation after vascular injury and the role of caveolin-1 in this process are not clear. To understand the protection effect of estrogen and caveolin-1, we employed a vascular balloon-injury model. Sixteen New Zealand White rabbits with or without estrogen were tested. 17 beta-estradiol is able to inhibit VSMC proliferation in a range from 10(-10)-10(-5) mol/L, with an optimal concentration of 10(-8) mol/L. Estrogen exerted its effect through suppressing the activity of p42/44 MAPK, which can be blocked by tamoxifen. Moreover, in estrogen pretreated cells as well as in common carotid arteries of the balloon injury model, expression of caveolin-1 is enhanced compared to the estrogen-deficient group, as assessed by both western blotting and RT-PCR and morphological studies. Our results showed that the inhibition effect of estrogen in VSMCs is mediated by p42/44 MAPK. Caveolin-1 plays an important role in this protective process. (c) 2006 Elsevier Inc. All rights reserved.
