The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.
The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.
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整个生命周期中庇护蛋白基因的差异时空表达模式
DOI：
10.18632/aging.101223
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Ye J
中科院分区：
文献类型：
--
作者：
Wagner KD;Ying Y;Leong W;Jiang J;Hu X;Chen Y;Michiels JF;Lu Y;Gilson E;Wagner N;Ye J
庇护蛋白形成端粒蛋白的核心复合物，并在保护端粒免受DNA损伤反应的不必要激活和维持端粒长度稳态中起关键作用。虽然shelterin表达被认为是普遍存在的稳定染色体末端，一些证据表明，一些shelterin亚基具有组织特异性功能。然而，很少有人知道如何shelterin亚基基因的表达在发育和衰老过程中进行调节。使用两种不同的动物模型，小鼠和斑马鱼，我们揭示了shelterin亚基表现出不同的空间和时间的表达模式，不相关的器官系统的增殖状态检查。总之，这项工作表明，shelterin亚基表现出不同的时空表达模式，这表明在整个生命周期的发展过程中重要的组织特异性功能。
Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in maintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends, some evidence suggests that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development throughout the lifespan.