The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence.
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence.
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DOI：
10.1038/nrc3958
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Harrington KJ
中科院分区：
文献类型：
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作者：
Barker HE;Paget JT;Khan AA;Harrington KJ
放射疗法在治疗癌症中起着重要作用。几十年来，大多数关于改善治疗结果的研究都集中在调节辐射对癌细胞的生物学效应上。最近，我们已经更好地理解了肿瘤微环境中的成分在决定治疗结果方面具有关键作用。在这篇综述中，我们描述了血管，基质和免疫学的变化诱导的肿瘤微环境辐射，并讨论他们如何可能促进放射抵抗和肿瘤复发。随后，我们强调了这些知识是如何指导新的治疗模式的发展，其中生物靶向药物将与放射治疗相结合。
Radiotherapy plays a central part in curing cancer. For decades, most research on improving treatment outcomes has focussed on modulating radiation-induced biological effects on cancer cells. Recently, we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. In this Review, we describe vascular, stromal and immunological changes induced in the tumour microenvironment by irradiation and discuss how they may promote radioresistance and tumour recurrence. Subsequently, we highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy.