Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes
Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes
复制标题
小鼠乳腺肿瘤病毒整合区int-1和int-2位于不同小鼠染色体上
DOI：
10.1128/mcb.4.2.375-378.1984
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发表时间：
1984
影响因子：
5.3
通讯作者：
C. Dickson
中科院分区：
文献类型：
--
作者：
G. Peters;C. Kozak;C. Dickson
在小鼠乳腺肿瘤病毒诱导的肿瘤中，小鼠DNA的两个区域构成了常见的前病毒整合位点，并被命名为INT-1和INT-2。通过对一系列仓鼠-小鼠体细胞杂交的研究，我们将INT-2基因定位到小鼠的7号染色体上，并证实了先前将INT-1定位在15号染色体上。这证明了INT-1和INT-2是离散的遗传座位。因此，两个不同细胞基因的前病毒激活可能导致相同的肿瘤疾病。
Two regions of mouse DNA which constitute common provirus integration sites in tumors induced by mouse mammary tumor virus have been identified and designated int-1 and int-2. By examining a series of hamster-mouse somatic cell hybrids, we mapped the int-2 locus to mouse chromosome 7 and confirmed the previous assignment of int-1 to chromosome 15. This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease.