A Functional Perspective on the Evolution of the Cochlea
A Functional Perspective on the Evolution of the Cochlea
复制标题
DOI：
10.1101/cshperspect.a033241
复制
发表时间：
2019-06-01
影响因子：
5.4
通讯作者：
Manley, Geoffrey A.
中科院分区：
文献类型：
--
作者：
Koeppl, Christine;Manley, Geoffrey A.
本文综述了古生物学资料以及对现存哺乳动物（单孔类、有袋类和胎盘类）耳蜗的形态、功能和分子进化的研究。最简单的假设是，具有内毛细胞和外毛细胞以及新生电活动性的特征性Corti器官的早期进化。大多数剩余的独特特征，如lagenar黄斑的损失，耳蜗的卷曲，以及支持基底膜的骨板，出现在后来，在单孔类谱系分离之后，但在有袋类和胎盘哺乳动物分化之前。听觉灵敏度何时首次扩展到超声波范围（此处定义为>20 kHz）的问题仍然是推测性的，尤其是因为最终哺乳动物中耳的出现较晚。最后一个重要的变化是优化了普雷斯廷的工作电压范围，从而优化了仅在胎盘谱系中外毛细胞放大作用的效率。
This review summarizes paleontological data as well as studies on the morphology, function, and molecular evolution of the cochlea of living mammals (monotremes, marsupials, and placenta Is). The most parsimonious scenario is an early evolution of the characteristic organ of Corti, with inner and outer hair cells and nascent electromotility. Most remaining unique features, such as loss of the lagenar macula, coiling of the cochlea, and bony laminae supporting the basilar membrane, arose later, after the separation of the monotreme lineage, but before marsupial and placental mammals diverged. The question of when hearing sensitivity first extended into the ultrasonic range (defined here as >20 kHz) remains speculative, not least because of the late appearance of the definitive mammalian middle ear. The last significant change was optimizing the operating voltage range of prestin, and thus the efficiency of the outer hair cells' amplifying action, in the placental lineage only.